(Q47817189)

5 February 2018

title

Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication (English)

1 reference

5 February 2018

3

Frank Kirchhoff

1 reference

5 February 2018

author name string

Enrique R Argañaraz

1

1 reference

5 February 2018

Michael Schindler

2

1 reference

5 February 2018

María J Cortes

4

1 reference

5 February 2018

Juan Lama

5

1 reference

5 February 2018

language of work or name

English

0 references

publication date

19 June 2003

1 reference

5 February 2018

Journal of Biological Chemistry

published in

1 reference

5 February 2018

volume

278

1 reference

5 February 2018

issue

36

1 reference

5 February 2018

page(s)

33912-33919

1 reference

5 February 2018

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: mechanism for persistence in AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Correlation between high level gp160 expression and reduced CD4 biosynthesis in clonal derivatives of human immunodeficiency virus type 1-infected U-937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

In vivo analysis of Nef function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Analysis of Nef-induced MHC-I endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Mechanism for down-regulation of CD28 by Nef.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Characterization of three nef-defective human immunodeficiency virus type 1 strains associated with long-term nonprogression. Australian Long-Term Nonprogressor Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

The physiological relevance of CD4 receptor down-modulation during HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Cell surface CD4 inhibits HIV-1 particle release by interfering with Vpu activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Partial "repair" of defective NEF genes in a long-term nonprogressor with human immunodeficiency virus type 1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Requirement of nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Coreceptor phenotype of natural human immunodeficiency virus with nef deleted evolves in vivo, leading to increased virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303679200

21 January 2018

Identifiers

DOI

10.1074/JBC.M303679200

1 reference

5 February 2018

1 reference

5 February 2018