(Q47820263)

5 February 2018

title

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics. (English)

1 reference

5 February 2018

author

Saikat Nandi

series ordinal

2

1 reference

5 February 2018

author name string

Sonali Bhattacharjee

series ordinal

1

1 reference

5 February 2018

publication date

1 December 2017

1 reference

5 February 2018

published in

IUBMB Life

1 reference

5 February 2018

volume

69

1 reference

5 February 2018

issue

12

1 reference

5 February 2018

page(s)

929-937

1 reference

5 February 2018

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

cites work

1 reference

Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

21 January 2018

1 reference

Double-strand break end resection and repair pathway choice

21 January 2018

1 reference

Mating-type genes and MAT switching in Saccharomyces cerevisiae

21 January 2018

1 reference

V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.

21 January 2018

1 reference

Dicer promotes transcription termination at sites of replication stress to maintain genome stability

21 January 2018

1 reference

Oxidatively induced DNA damage and its repair in cancer

21 January 2018

1 reference

DNA damage responses and stress resistance: Concepts from bacterial SOS to metazoan immunity

21 January 2018

1 reference

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

DNA Damage, Aging, and Cancer

21 January 2018

1 reference

Genome maintenance mechanisms for preventing cancer

21 January 2018

1 reference

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

1 reference

DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

21 January 2018

1 reference

DNA repair targeted therapy: The past or future of cancer treatment?

21 January 2018

1 reference

Repair and genetic consequences of endogenous DNA base damage in mammalian cells

21 January 2018

1 reference

UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair

21 January 2018

1 reference

Molecular mechanisms of mammalian global genome nucleotide excision repair.

21 January 2018

1 reference

New insights into the mechanism of DNA mismatch repair

21 January 2018

1 reference

Base excision repair: a critical player in many games

21 January 2018

1 reference

Transcription-coupled DNA repair: two decades of progress and surprises

21 January 2018

1 reference

Regulation of endonuclease activity in human nucleotide excision repair

21 January 2018

1 reference

Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA.

21 January 2018

1 reference

Eukaryotic DNA mismatch repair

21 January 2018

1 reference

21 January 2018

1 reference

Mismatch repair in replication fidelity, genetic recombination, and cancer biology

21 January 2018

1 reference

Mechanisms and functions of DNA mismatch repair

21 January 2018

1 reference

How does DNA break during chromosomal translocations?

21 January 2018

1 reference

Regulation of homologous recombination in eukaryotes

21 January 2018

1 reference

Regulation of DNA double-strand break repair pathway choice

21 January 2018

1 reference

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

21 January 2018

1 reference

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

21 January 2018

1 reference

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

21 January 2018

1 reference

Replisome assembly and the direct restart of stalled replication forks

21 January 2018

1 reference

Meiotic chromosomes: integrating structure and function

21 January 2018

1 reference

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

21 January 2018

1 reference

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

21 January 2018

1 reference

Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.

21 January 2018

1 reference

Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?

21 January 2018

1 reference

Identification of Holliday junction resolvases from humans and yeast

21 January 2018

1 reference

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant

21 January 2018

1 reference

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

21 January 2018

1 reference

Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair

21 January 2018

1 reference

Chiasma formation: chromatin/axis interplay and the role(s) of the synaptonemal complex

21 January 2018

1 reference

MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination

21 January 2018

1 reference

The ATPase activity of Fml1 is essential for its roles in homologous recombination and DNA repair

21 January 2018

1 reference

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair

21 January 2018

1 reference

RTEL1 maintains genomic stability by suppressing homologous recombination

21 January 2018

1 reference

The Srs2 helicase activity is stimulated by Rad51 filaments on dsDNA: implications for crossover incidence during mitotic recombination

21 January 2018

1 reference

The fission yeast FANCM ortholog directs non-crossover recombination during meiosis

21 January 2018

1 reference

Break-induced replication: functions and molecular mechanism

21 January 2018

1 reference

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy

21 January 2018

1 reference

Global synthetic-lethality analysis and yeast functional profiling

21 January 2018

1 reference

Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line

21 January 2018

1 reference

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

21 January 2018

1 reference

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate

21 January 2018

1 reference

The base excision repair: mechanisms and its relevance for cancer susceptibility

21 January 2018

1 reference

Poly(ADP-ribose): novel functions for an old molecule

21 January 2018

1 reference

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

21 January 2018

1 reference

The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings

21 January 2018

1 reference

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

21 January 2018

1 reference

Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study

21 January 2018

1 reference

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

21 January 2018

1 reference

Tumor neoantigens: building a framework for personalized cancer immunotherapy

21 January 2018

1 reference

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

21 January 2018

1 reference

A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts

21 January 2018

1 reference

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines

21 January 2018

1 reference

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

1 reference

Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation

21 January 2018

1 reference

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

21 January 2018

1 reference

DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway

21 January 2018

1 reference

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

21 January 2018

1 reference

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

21 January 2018

1 reference

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.

21 January 2018

1 reference

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

21 January 2018

1 reference

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression

21 January 2018

1 reference

A phase II study of the potent PARP inhibitor, Rucaparib (PF-01367338, AG014699), with temozolomide in patients with metastatic melanoma demonstrating evidence of chemopotentiation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IUB.1696

1 reference

5 February 2018

release_33ltz3gchbhzzdgrw5ck4ggg2i

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/33ltz3gchbhzzdgrw5ck4ggg2i

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

29171189

1 reference

5 February 2018