(Q47833436)

6 February 2018

title

PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum (English)

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6 February 2018

main subject

molecular chaperones

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endoplasmic reticulum

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Thea Bismo Strøm

1

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6 February 2018

Kristian Tveten

series ordinal

2

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6 February 2018

Trond P Leren

series ordinal

3

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6 February 2018

language of work or name

English

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publication date

1 January 2014

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6 February 2018

published in

Biochemical Journal

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6 February 2018

volume

457

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6 February 2018

issue

1

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6 February 2018

page(s)

99-105

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6 February 2018

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Molecular basis for LDL receptor recognition by PCSK9

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Characterization of novel mutations in the catalytic domain of the PCSK9 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Characterization of a naturally occurring degradation product of the LDL receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Proteomic Analysis of Proteins Secreted by HepG2 Cells Treated with Butyl Benzyl Phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Characterization of residues in the cytoplasmic domain of the LDL receptor required for exit from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Integrating the cell stress response: a new view of molecular chaperones as immunological and physiological homeostatic regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Secreted heat shock protein-90 (Hsp90) in wound healing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

Functional analysis of sites within PCSK9 responsible for hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130930

21 January 2018

Identifiers

DOI

10.1042/BJ20130930

1 reference

6 February 2018

1 reference

6 February 2018