(Q24303660)

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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation (English)

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Proprotein convertase subtilisin/kexin type 9

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GOA release 2020-03-11

low-density lipoprotein particle receptor binding

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GOA release 2020-03-11

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inferred from title

8

object named as

Helen H Hobbs

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6

object named as

Jay D Horton

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Jonathan C. Cohen

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object named as

Jonathan C Cohen

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author name string

Da-Wei Zhang

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Thomas A Lagace

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Rita Garuti

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Zhenze Zhao

4

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Meghan McDonald

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language of work or name

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publication date

22 June 2007

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Journal of Biological Chemistry

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282

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25

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18602-12

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Molecular genetics of the LDL receptor gene in familial hypercholesterolemia

1 reference

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An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components

1 reference

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NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

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The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

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The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

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Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

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The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors

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Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor

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Molecular biology of PCSK9: its role in LDL metabolism

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Calcium-binding EGF-like modules in coagulation proteinases: function of the calcium ion in module interactions

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Solution structure of the LDL receptor EGF-AB pair: a paradigm for the assembly of tandem calcium binding EGF domains

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The first epidermal growth factor-like domain of the low-density lipoprotein receptor contains a noncanonical calcium binding site

1 reference

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Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

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Inhibition of G1 cyclin activity by the Ras/cAMP pathway in yeast

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Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

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Reading protein modifications with interaction domains

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Intraperitoneal cisplatin and paclitaxel in ovarian cancer.

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

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Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin

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Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair

1 reference

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NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

1 reference

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

1 reference

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Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8.

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

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Hybrid cell lines constitute a potential reservoir of polarized cells: isolation and study of highly differentiated hepatoma-derived hybrid cells able to form functional bile canaliculi in vitro

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

1 reference

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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

1 reference

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

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Evolution of distinct EGF domains with specific functions

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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia

1 reference

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based on heuristic

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A receptor-mediated pathway for cholesterol homeostasis

1 reference

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based on heuristic

inferred from DOI database lookup

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

1 reference

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

1 reference

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Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly

1 reference

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Identifiers

10.1074/JBC.M702027200

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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