(Q24299848)

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications (English)

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Proprotein convertase subtilisin/kexin type 5

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GOA release 2020-03-11

Furin, paired basic amino acid cleaving enzyme

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GOA release 2020-03-11

Proprotein convertase subtilisin/kexin type 9

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GOA release 2020-03-11

signal peptide processing

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GOA release 2020-03-11

object named as

Nabil G Seidah

5

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author name string

Suzanne Benjannet

1

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David Rhainds

2

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Josée Hamelin

3

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Nasha Nassoury

4

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language of work or name

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publication date

13 October 2006

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Journal of Biological Chemistry

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281

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41

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30561-72

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Functional characterization of Narc 1, a novel proteinase related to proteinase K

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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

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A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.

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Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy

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Dual regulation of the LDL receptor--some clarity and new questions

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

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Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors

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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

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The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity

1 reference

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Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse

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Limited redundancy of the proprotein convertase furin in mouse liver

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10.1074/JBC.M606495200

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