(Q21130010)

peptidase S8, subtilisin-related

1 reference

Peptidase S8/S53 domain superfamily

1 reference

Proteinase K-like catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase S8 propeptide/proteinase inhibitor I9, protein family

1 reference

based on heuristic

inferred from protein domain or family

Subtilase

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

apolipoprotein receptor binding

1 reference

8 April 2019

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

Self-association of human PCSK9 correlates with its LDLR-degrading activity

protein self-association

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

sodium channel inhibitor activity

1 reference

8 April 2019

Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

low-density lipoprotein particle receptor binding

4 references

8 April 2019

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

very-low-density lipoprotein particle receptor binding

1 reference

8 April 2019

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

7 references

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

serine-type peptidase activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

signaling receptor inhibitor activity

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

serine-type endopeptidase activity

HDA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

rough endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

extrinsic component of external side of plasma membrane

1 reference

8 April 2019

Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

IC

endoplasmic reticulum

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

perinuclear region of cytoplasm

1 reference

8 April 2019

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

COPII-coated ER to Golgi transport vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7

17 October 2017

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7

17 October 2017

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7

17 October 2017

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NBP7&geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

endolysosome membrane

1 reference

8 April 2019

endoplasmic reticulum lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

lipoprotein metabolic process

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

steroid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

positive regulation of receptor internalization

1 reference

8 April 2019

Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

negative regulation of low-density lipoprotein particle clearance

negative regulation of sodium ion transmembrane transporter activity

1 reference

8 April 2019

Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

regulation of low-density lipoprotein particle receptor catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

regulation of signaling receptor activity

1 reference

8 April 2019

Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

2 references

positive regulation of low-density lipoprotein particle receptor catabolic process

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

low-density lipoprotein receptor particle metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

1 reference

8 April 2019

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

phospholipid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

triglyceride metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

negative regulation of receptor recycling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

negative regulation of low-density lipoprotein particle receptor binding

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

negative regulation of low-density lipoprotein receptor activity

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

negative regulation of receptor-mediated endocytosis involved in cholesterol transport

1 reference

8 April 2019

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

low-density lipoprotein particle receptor catabolic process

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

Self-association of human PCSK9 correlates with its LDLR-degrading activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

8 April 2019

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

low-density lipoprotein particle clearance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

post-translational protein modification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

negative regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NBP7

physically interacts with

evolocumab

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2364655

Bococizumab

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3137349

has part(s)

peptidase S8 propeptide/proteinase inhibitor I9

1 reference

peptidase S8/S53 domain

1 reference

Proteinase K-like catalytic domain

1 reference

D08.811.277.656.300.760.718

Commons category

PCSK9

0 references

Identifiers

MeSH descriptor ID

D000071449

subject named as

Proprotein Convertase 9

0 references

MeSH tree code

0 references

D08.811.277.656.837.688

0 references

D08.811.277.656.959.350.718

0 references

1 reference

22 November 2019

1 reference

13 November 2019

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016

1 reference

21 March 2016