(Q24321435)

English

Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor

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scholarly article

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Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor (English)

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Apolipoprotein B

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GOA release 2020-03-11

apolipoprotein B mRNA editing enzyme catalytic subunit 1

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GOA release 2020-03-11

Proprotein convertase subtilisin/kexin type 9

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GOA release 2020-03-11

Proprotein convertase subtilisin/kexin type 9

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GOA release 2020-03-11

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based on heuristic

inferred from title

author name string

Hua Sun

1

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Amin Samarghandi

2

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Ningyan Zhang

3

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Zemin Yao

4

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Momiao Xiong

5

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Ba-Bie Teng

6

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language of work or name

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publication date

July 2012

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Arteriosclerosis, Thrombosis, and Vascular Biology

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32

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7

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1585-95

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Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration

1 reference

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Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B.

1 reference

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Autophagy: cellular and molecular mechanisms

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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree

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Differential expression of genes in the calcium-signaling pathway underlies lesion development in the LDb mouse model of atherosclerosis

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The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells

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Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase

1 reference

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Molecular biology of PCSK9: its role in LDL metabolism

1 reference

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Hepatic gene expression profiling reveals perturbed calcium signaling in a mouse model lacking both LDL receptor and Apobec1 genes

1 reference

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Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B

1 reference

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

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A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

1 reference

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Diagnosis and treatment of apolipoprotein B dyslipoproteinemias.

1 reference

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Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor

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Purification and characterization of autophagosomes from rat hepatocytes

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Increased plasma non-esterified fatty acids and platelet-activating factor acetylhydrolase are associated with susceptibility to atherosclerosis in mice

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

1 reference

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

1 reference

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

1 reference

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Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control

1 reference

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7 January 2021

based on heuristic

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Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B

1 reference

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7 January 2021

based on heuristic

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Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

1 reference

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7 January 2021

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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

1 reference

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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

1 reference

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7 January 2021

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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications

1 reference

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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

1 reference

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7 January 2021

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Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia

1 reference

https://api.crossref.org/works/10.1161%2FATVBAHA.112.250043

7 January 2021

based on heuristic

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Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB.

1 reference

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7 January 2021

based on heuristic

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Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins

1 reference

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Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors

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Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B.

1 reference

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7 January 2021

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Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia

1 reference

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Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted

1 reference

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Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

1 reference

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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

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A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

1 reference

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice

1 reference

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7 January 2021

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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo

1 reference

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Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells

1 reference

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7 January 2021

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PCSK9: a convertase that coordinates LDL catabolism

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor.

1 reference

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7 January 2021

based on heuristic

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