(Q47848197)

6 February 2018

title

Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype (English)

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6 February 2018

juvenile neuronal ceroid lipofuscinosis

main subject

microglia

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Juan Xiong

1

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6 February 2018

Tammy Kielian

series ordinal

2

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6 February 2018

language of work or name

English

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publication date

22 August 2013

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6 February 2018

Journal of Neurochemistry

published in

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6 February 2018

volume

127

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6 February 2018

issue

2

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6 February 2018

page(s)

245-258

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6 February 2018

Free radicals in viral pathogenesis: molecular mechanisms involving superoxide and NO.

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Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease.

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Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin

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Altered sensitivity of cerebellar granule cells to glutamate receptor overactivation in the Cln3(Δex7/8)-knock-in mouse model of juvenile neuronal ceroid lipofuscinosis

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Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

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Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

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Toll-like receptor (TLR) and inflammasome actions in the central nervous system

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Developmental impairments of select neurotransmitter systems in brains of Cln3(Deltaex7/8) knock-in mice, an animal model of juvenile neuronal ceroid lipofuscinosis

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Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response.

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Critical functions of priming and lysosomal damage for NLRP3 activation

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Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease.

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Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation

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Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity

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Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury.

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Attenuation of AMPA receptor activity improves motor skills in a mouse model of juvenile Batten disease

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Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

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Temporary inhibition of AMPA receptors induces a prolonged improvement of motor performance in a mouse model of juvenile Batten disease

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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.

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IgG entry and deposition are components of the neuroimmune response in Batten disease.

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MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection

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Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate

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Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.

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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

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Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

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Ceramide function in the brain: when a slight tilt is enough.

21 January 2018

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Functions of connexins and large pore channels on microglial cells: the gates to environment

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Spectrum of mutations in the Batten disease gene, CLN3

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Critical role for calcium mobilization in activation of the NLRP3 inflammasome

21 January 2018

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Neurodevelopmental delay in the Cln3Deltaex7/8 mouse model for Batten disease

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Storage bodies in the ceroid-lipofuscinoses (Batten disease): low-molecular-weight components, unusual amino acids and reconstitution of fluorescent bodies from non-fluorescent components

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Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders

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Cell death pathways in juvenile Batten disease

21 January 2018

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

21 January 2018

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Late onset neurodegeneration in the Cln3-/- mouse model of juvenile neuronal ceroid lipofuscinosis is preceded by low level glial activation.

21 January 2018

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Thalamocortical neuron loss and localized astrocytosis in the Cln3Deltaex7/8 knock-in mouse model of Batten disease.

21 January 2018

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Juvenile neuronal ceroid-lipofuscinosis (Batten disease): a brief review and update

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The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase

21 January 2018

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Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

21 January 2018

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Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential

21 January 2018

1 reference

The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol

21 January 2018

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A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses

21 January 2018

1 reference

Gliotransmission and the tripartite synapse

21 January 2018

1 reference

Immunosuppression alters disease severity in juvenile Batten disease mice

21 January 2018

1 reference

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

21 January 2018

1 reference

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

21 January 2018

1 reference

Interleukin-15 biology and its therapeutic implications in cancer

21 January 2018

1 reference

Synaptic scaling mediated by glial TNF-alpha

21 January 2018

1 reference

Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release.

21 January 2018

1 reference

The Batten disease gene CLN3 is required for the response to oxidative stress.

21 January 2018

1 reference

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

21 January 2018

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Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).

21 January 2018

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A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.12385

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6 February 2018

PubMed ID

23919525

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6 February 2018