(Q47859631)

6 February 2018

title

Thermodynamics and molecular simulation analysis of hydrophobic substrate recognition by aminotransferases. (English)

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6 February 2018

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Kawaguchi S

1

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6 February 2018

Kuramitsu S

series ordinal

2

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6 February 2018

language of work or name

English

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publication date

1 July 1998

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6 February 2018

Journal of Biological Chemistry

published in

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6 February 2018

volume

273

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6 February 2018

page(s)

18353-18364

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6 February 2018

issue

29

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6 February 2018

Enzyme flexibility: a new concept in recognition of hydrophobic substrates.

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The specificity in the elementary steps of alpha-chymotrypsin catalysis. A temperature study with a series of N-acetyl-L-amino acid methyl esters.

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Effect of cavity-creating mutations in the hydrophobic core of chymotrypsin inhibitor 2

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Dependence of conformational stability on hydrophobicity of the amino acid residue in a series of variant proteins substituted at a unique position of tryptophan synthase alpha subunit

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Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

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Energetics of repacking a protein interior

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Evolutionary recruitment of biochemically specialized subdivisions of Family I within the protein superfamily of aminotransferases

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Escherichia coli aromatic amino acid aminotransferase: characterization and comparison with aspartate aminotransferase

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Pyridoxal phosphate-dependent enzymes

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Pyridoxal enzymes: mechanistic diversity and uniformity

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2.8-A-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli

21 January 2018

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X-ray crystallographic study of pyridoxal 5'-phosphate-type aspartate aminotransferases from Escherichia coli in open and closed form

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Refinement and comparisons of the crystal structures of pig cytosolic aspartate aminotransferase and its complex with 2-methylaspartate

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Aspartate aminotransferase of Escherichia coli: nucleotide sequence of the aspC gene

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Construction of aminotransferase chimeras and analysis of their substrate specificity.

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Protonation state of the active-site Schiff base of aromatic amino acid aminotransferase: modulation by binding of ligands and implications for its role in catalysis.

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Molecular-dynamics simulation of domain movements in aspartate aminotransferase.

21 January 2018

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The use of natural and unnatural amino acid substrates to define the substrate specificity differences of Escherichia coli aspartate and tyrosine aminotransferases

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X-ray crystallographic study of pyridoxamine 5'-phosphate-type aspartate aminotransferases from Escherichia coli in three forms

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

21 January 2018

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Active-site Arg --> Lys substitutions alter reaction and substrate specificity of aspartate aminotransferase.

21 January 2018

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Syncatalytic conformational changes in aspartate aminotransferase determined by hydrogen-deuterium exchange

21 January 2018

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Comparison of straight chain and cyclic unnatural amino acids embedded in the core of staphylococcal nuclease

21 January 2018

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Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues

21 January 2018

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Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

21 January 2018

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Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism

21 January 2018

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Converting trypsin to chymotrypsin: the role of surface loops

21 January 2018

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Structural origins of substrate discrimination in trypsin and chymotrypsin

21 January 2018

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Kinetic and structural characterization of mutations of glycine 216 in alpha-lytic protease: a new target for engineering substrate specificity

21 January 2018

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Functional linkage between the active site of alpha-lytic protease and distant regions of structure: scanning alanine mutagenesis of a surface loop affects activity and substrate specificity

21 January 2018

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Conformational substates in enzyme mechanism: the 120 K structure of alpha-lytic protease at 1.5 A resolution

21 January 2018

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Redesign of the substrate specificity of Escherichia coli aspartate aminotransferase to that of Escherichia coli tyrosine aminotransferase by homology modeling and site-directed mutagenesis

21 January 2018

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Crystal structures of holo and apo-cellular retinol-binding protein II

21 January 2018

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X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase

21 January 2018

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Domain closure in mitochondrial aspartate aminotransferase

21 January 2018

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Crystal structure of the closed form of chicken cytosolic aspartate aminotransferase at 1.9 A resolution

21 January 2018

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Improved Binding of Cytochrome P450cam Substrate Analogues Designed To Fill Extra Space in the Substrate Binding Pocket†

21 January 2018

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Thermodynamics of Ligand Binding to Acyl-Coenzyme A Binding Protein Studied by Titration Calorimetry†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.29.18353

1 reference

6 February 2018

PubMed ID

9660802

1 reference

6 February 2018