(Q47864266)

English

Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.

scientific article published in July 2013

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scholarly article

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6 March 2020

Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging (English)

1 reference

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6 March 2020

Christoph Schwarzer

6

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6 March 2020

Caroline Ménard

1

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6 March 2020

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6 March 2020

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Rémi Quirion

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6 March 2020

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Yiu Chung Tse

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6 March 2020

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Jean-Guy Chabot

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Jean-Guy Chabot

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6 March 2020

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Chelsea Cavanagh

3

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Chelsea Cavanagh

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6 March 2020

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author name string

Herbert Herzog

5

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6 March 2020

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publication date

1 July 2013

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6 March 2020

Journal of Neuroscience

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6 March 2020

33

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6 March 2020

31

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6 March 2020

12792-12804

1 reference

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6 March 2020

Stress and hippocampal plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of preprodynorphin and preproenkephalin mRNA expression by selective activation of group I metabotropic glutamate receptors in characterized primary cultures of rat striatal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynorphin increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aged neuropeptide Y transgenic rats are resistant to acute stress but maintain spatial and non-spatial learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in brain proDynorphin gene expression in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor-independent long-term depression correlates with successful aging in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A glutamate antagonist blocks perforant path stimulation-induced reduction of dynorphin peptide and prodynorphin mRNA levels in rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of dynorphins in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal long-term depression: master or minion in declarative memory processes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immediate-early gene expression at rest recapitulates recent experience.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of long-term depression underlies visual recognition memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGluR5 has a critical role in inhibitory learning.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

30 years of dynorphins--new insights on their functions in neuropsychiatric diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microinjection of dynorphin into the hippocampus impairs spatial learning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal long-term depression is required for the consolidation of spatial memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-associated deficits in pattern separation functions of the perirhinal cortex: a cross-species consensus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced activation of the dynorphin/κ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significant increase in anxiety during aging in mGlu5 receptor knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of normal aging: relationship between cognitive decline and markers in hippocampal circuitry

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the opioid system in the anxiolytic effect of diazepam in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivity to novelty in cognitively-impaired and cognitively-unimpaired aged rats and young rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal dynorphin B injections impair spatial learning in rats: a kappa-opioid receptor-mediated effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of corticotropin-releasing factor in depression and anxiety disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23904614

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0290-13.2013

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23904614%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23904614%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23904614%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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