(Q47878238)

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Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability.

scientific article published in August 2004

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15044965%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Mechanism of action of Drosophila Reaper in mammalian cells: Reaper globally inhibits protein synthesis and induces apoptosis independent of mitochondrial permeability (English)

1 reference

Europe PubMed Central

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26 December 2019

1

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Europe PubMed Central

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26 December 2019

author name string

A B Werner

2

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26 December 2019

E de Vries

3

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26 December 2019

J Borst

4

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26 December 2019

publication date

1 August 2004

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26 December 2019

Cell Death & Differentiation

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26 December 2019

11

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26 December 2019

8

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26 December 2019

800-811

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15044965%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

Apoptosis in development

1 reference

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Cell death regulation in Drosophila: conservation of mechanism and unique insights

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Cell killing by the Drosophila gene reaper

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Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs).

1 reference

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Genetic control of programmed cell death in Drosophila

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The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper

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Drosophila p53 binds a damage response element at the reaper locus

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IAP family proteins--suppressors of apoptosis

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

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The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

1 reference

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7 January 2021

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Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

1 reference

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7 January 2021

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The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

1 reference

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7 January 2021

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Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.

1 reference

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7 January 2021

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Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

1 reference

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7 January 2021

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Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition

1 reference

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7 January 2021

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The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

1 reference

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7 January 2021

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sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein

1 reference

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7 January 2021

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Drosophila sickle is a novel grim-reaper cell death activator

1 reference

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7 January 2021

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Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1

1 reference

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7 January 2021

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The proapoptotic function of Drosophila Hid is conserved in mammalian cells

1 reference

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7 January 2021

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

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7 January 2021

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

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7 January 2021

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

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7 January 2021

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Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

1 reference

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7 January 2021

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The role of ARK in stress-induced apoptosis in Drosophila cells

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7 January 2021

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GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway

1 reference

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7 January 2021

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A Bax/Bak-independent mitochondrial death pathway triggered by Drosophila Grim GH3 domain in mammalian cells

1 reference

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7 January 2021

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Reaper-induced apoptosis in a vertebrate system

1 reference

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7 January 2021

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Scythe: a novel reaper-binding apoptotic regulator.

1 reference

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Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity

1 reference

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Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

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7 January 2021

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Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

1 reference

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7 January 2021

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Reaper is regulated by IAP-mediated ubiquitination.

1 reference

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7 January 2021

based on heuristic

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Altered cytochrome c display precedes apoptotic cell death in Drosophila

1 reference

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The role of cytochrome c in caspase activation in Drosophila melanogaster cells

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Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator

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Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway

1 reference

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Characterization of reaper- and FADD-induced apoptosis in a lepidopteran cell line

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7 January 2021

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reaper and bax initiate two different apoptotic pathways affecting mitochondria and antagonized by bcl-2 in Drosophila.

1 reference

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7 January 2021

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Drosophila grim induces apoptosis in mammalian cells.

1 reference

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A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation

1 reference

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A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain

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Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis

1 reference

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Inhibition of Translation and Induction of Apoptosis by Bunyaviral Nonstructural Proteins Bearing Sequence Similarity to Reaper

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Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

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Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax

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Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

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A new quantitative assay for cytochrome c release in apoptotic cells.

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