(Q47936492)

6 February 2018

title

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies (English)

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6 February 2018

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Thomas Calzascia

2

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Marc Pellegrini

Marc Pellegrini

1

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Pamela Ohashi

Pamela S Ohashi

14

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Tak Wah Mak

15

Tak W Mak

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6 February 2018

Michel Morre

10

Michel Morre

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6 February 2018

Brigitte Assouline

11

Brigitte Assouline

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6 February 2018

Salim Dhanji

7

Salim Dhanji

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6 February 2018

Arda Shahinian

4

Arda Shahinian

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6 February 2018

Alisha R Elford

3

Alisha R Elford

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6 February 2018

Dilan Dissanayake

6

Dilan Dissanayake

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6 February 2018

author name string

Amy E Lin

5

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6 February 2018

Linh T Nguyen

8

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6 February 2018

Matthew A Gronski

9

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6 February 2018

Katharina Lahl

12

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6 February 2018

Tim Sparwasser

13

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6 February 2018

language of work or name

English

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publication date

26 April 2009

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6 February 2018

published in

Nature Medicine

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6 February 2018

volume

15

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6 February 2018

issue

5

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6 February 2018

page(s)

528-536

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6 February 2018

Cutting Edge: Limiting amounts of IL-7 do not control contraction of CD4+ T cell responses

cites work

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IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis

21 January 2018

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Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo

21 January 2018

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Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice

21 January 2018

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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

21 January 2018

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12 December 2020

Intratumoral administration of adenoviral interleukin 7 gene-modified dendritic cells augments specific antitumor immunity and achieves tumor eradication

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12 December 2020

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

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12 December 2020

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

1 reference

12 December 2020

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

1 reference

12 December 2020

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

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12 December 2020

New battlefields for costimulation

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12 December 2020

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

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12 December 2020

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors

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12 December 2020

Interleukin-7: from bench to clinic

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12 December 2020

Interleukin 7 promotes long-term in vitro growth of antitumor cytotoxic T lymphocytes with immunotherapeutic efficacy in vivo

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12 December 2020

TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice

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12 December 2020

Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors.

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12 December 2020

Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool

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12 December 2020

TCR affinity and negative regulation limit autoimmunity

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12 December 2020

Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo

1 reference

12 December 2020

Immune resistance orchestrated by the tumor microenvironment

1 reference

12 December 2020

Immunosuppressive networks in the tumour environment and their therapeutic relevance

1 reference

12 December 2020

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

1 reference

12 December 2020

Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation

1 reference

12 December 2020

Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia

1 reference

12 December 2020

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

12 December 2020

Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection

1 reference

12 December 2020

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

12 December 2020

Cancer immunologists and cancer biologists: why we didn't talk then but need to now

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12 December 2020

Vascular targeting, chemotherapy and active immunotherapy: teaming up to attack cancer

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12 December 2020

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis

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12 December 2020

Interleukin-7 restores immunity in athymic T-cell-depleted hosts

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12 December 2020

E3 ubiquitin ligases as T cell anergy factors.

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12 December 2020

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

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12 December 2020

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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12 December 2020

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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12 December 2020

IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells

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12 December 2020

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

1 reference

12 December 2020

Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

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12 December 2020

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

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12 December 2020

Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation

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12 December 2020

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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12 December 2020

Tumor-specific Th17-polarized cells eradicate large established melanoma

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12 December 2020

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

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12 December 2020

T-lymphocyte death during shutdown of an immune response

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12 December 2020

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

1 reference

12 December 2020

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

1 reference

12 December 2020

The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells

1 reference

12 December 2020

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

1 reference

12 December 2020

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

1 reference

12 December 2020

Cbl-b regulates the CD28 dependence of T-cell activation.

1 reference

12 December 2020

Tumor cells cotransfected with interleukin-7 and B7.1 genes induce CD25 and CD28 on tumor-infiltrating T lymphocytes and are strong vaccines

1 reference

12 December 2020

Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice

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12 December 2020

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

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12 December 2020

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.

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12 December 2020

Identifiers

DOI

10.1038/NM.1953

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6 February 2018

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6 February 2018