(Q47948196)

7 February 2018

title

The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid (English)

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7 February 2018

Mycobacterium tuberculosis

main subject

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5

Via LE

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7 February 2018

Subramanian Dhandayuthapani

4

object named as

Dhandayuthapani S

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7 February 2018

Vojo Deretic

1

object named as

Deretic V

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7 February 2018

Pagán-Ramos E

2

object named as

Pagán-Ramos E

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7 February 2018

author name string

Zhang Y

3

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7 February 2018

publication date

1 November 1996

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7 February 2018

published in

Nature Biotechnology

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7 February 2018

volume

14

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7 February 2018

issue

11

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7 February 2018

page(s)

1557-1561

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7 February 2018

The global tuberculosis situation and the new control strategy of the World Health Organization

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

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1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

21 January 2018

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Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid

21 January 2018

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Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages

21 January 2018

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Isoniazid interaction with tyrosine as a possible mode of action of the drug in mycobacteria

21 January 2018

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Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum

21 January 2018

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Enzymatic and nonenzymatic superoxide-generating reactions of isoniazid

21 January 2018

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Evidence for the generation of active oxygen by isoniazid treatment of extracts of Mycobacterium tuberculosis H37Ra

21 January 2018

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Peroxidase-mediated oxidation of isoniazid

21 January 2018

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The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNBT1196-1557

Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.

21 January 2018

1 reference

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Mutations in katG gene sequences in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis are rare

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

21 January 2018

1 reference

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The katE gene, which encodes the catalase HPII of Mycobacterium avium.

21 January 2018

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Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid

21 January 2018

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Molecular biology of the LysR family of transcriptional regulators

21 January 2018

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Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum.

21 January 2018

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ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex

21 January 2018

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Tuberculosis: commentary on a reemergent killer

21 January 2018

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7 January 2021

The ins and outs of protein splicing elements

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7 January 2021

Immunopathology of tuberculosis: roles of macrophages and monocytes

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7 January 2021

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

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7 January 2021

Mycobacterium and Leishmania: stowaways in the endosomal network

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7 January 2021

Leprosy, tuberculosis, and the new genetics

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7 January 2021

Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis

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https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

The purification and properties of peroxidase in Mycobacterium tuberculosis H37Rv and its possible role in the mechanism of action of isonicotinic acid hydrazide

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Metabolism of nicotinamide adenine dinucleotide in human and bovine strainsof Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Catalase and peroxidase in mycobacteria. Possible relationship to the mode of action of isoniazid

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Oxidation of isonicotinic acid hydrazide by the peroxidase system. The formation of an excited product

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: a mechanism for differential promoter selection

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli.

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis.

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

MycDB: an integrated mycobacterial database

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.

1 reference

https://api.crossref.org/works/10.1038%2FNBT1196-1557

7 January 2021

Identifiers

DOI

10.1038/NBT1196-1557

1 reference

7 February 2018

1 reference

7 February 2018