(Q48026242)

7 February 2018

title

Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication? (English)

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7 February 2018

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1

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7 February 2018

Annapaola Franchitto

series ordinal

2

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7 February 2018

language of work or name

English

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publication date

1 March 2004

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7 February 2018

published in

BioEssays

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7 February 2018

volume

26

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7 February 2018

issue

3

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7 February 2018

page(s)

306-313

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7 February 2018

Links between replication, recombination and genome instability in eukaryotes

cites work

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The Mre11 complex and ATM: collaborating to navigate S phase

21 January 2018

1 reference

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

1 reference

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Rescue of arrested replication forks by homologous recombination

21 January 2018

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Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10411

The DNA replication checkpoint response stabilizes stalled replication forks

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10411

The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIES.10411

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Checking on the fork: the DNA-replication stress-response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

DNA recombination: the replication connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Genetic linkage of Werner's syndrome to five markers on chromosome 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The Werner syndrome protein is a DNA helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Functional and physical interaction between WRN helicase and human replication protein A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Functional interaction between Ku and the werner syndrome protein in DNA end processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Physical and functional interaction between p53 and the Werner's syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

p53 Modulates the exonuclease activity of Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Functional interaction between the Werner Syndrome protein and DNA polymerase delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Spontaneous and X-ray-induced chromosomal aberrations in Werner syndrome cells detected by FISH using chromosome-specific painting probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

DNA damage checkpoints update: getting molecular

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

Expansion and length-dependent fragility of CTG repeats in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

The many interfaces of Mre11

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.10411

21 January 2018

Identifiers

DOI

10.1002/BIES.10411

1 reference

7 February 2018

release_o3ub7voitnbmza2sn6ed6wejfu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o3ub7voitnbmza2sn6ed6wejfu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

7 February 2018