(Q48100849)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251726%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

title

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens (English)

1 reference

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7 April 2020

0 references

0 references

2

1 reference

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7 April 2020

Mudra Hegde

4

1 reference

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7 April 2020

Meagan E Sullender

7

1 reference

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7 April 2020

Nicolo Fusi

10

1 reference

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7 April 2020

Jennifer Listgarten

11

1 reference

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7 April 2020

John G Doench

15

1 reference

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7 April 2020

14

David E Root

1 reference

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7 April 2020

13

Bradley E Bernstein

1 reference

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7 April 2020

author name string

Fadi J Najm

1

1 reference

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7 April 2020

Katherine F Donovan

3

1 reference

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7 April 2020

Kendall R Sanson

5

1 reference

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7 April 2020

Emma W Vaimberg

6

1 reference

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7 April 2020

Ella Hartenian

8

1 reference

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7 April 2020

Zohra Kalani

9

1 reference

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7 April 2020

Scott T Younger

12

1 reference

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7 April 2020

publication date

18 December 2017

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7 April 2020

1 reference

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7 April 2020

volume

36

1 reference

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7 April 2020

issue

2

1 reference

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7 April 2020

page(s)

179-189

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https://scigraph.springernature.com/pub.10.1038/nbt.4048

7 April 2020

exact match

0 references

cites work

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

1 reference

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Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

10 July 2018

1 reference

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A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

10 July 2018

1 reference

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Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions

10 July 2018

1 reference

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Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array

10 July 2018

1 reference

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COSMIC: somatic cancer genetics at high-resolution

10 July 2018

1 reference

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Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library

10 July 2018

1 reference

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Complex transcriptional modulation with orthogonal and inducible dCas9 regulators.

10 July 2018

1 reference

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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

A global genetic interaction network maps a wiring diagram of cellular function

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.

10 July 2018

1 reference

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Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

10 July 2018

1 reference

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In vivo genome editing using Staphylococcus aureus Cas9

10 July 2018

1 reference

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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

10 July 2018

1 reference

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Highly efficient Cas9-mediated transcriptional programming

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies

10 July 2018

1 reference

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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Discovery and saturation analysis of cancer genes across 21 tumour types

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Inactivating CUX1 mutations promote tumorigenesis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Structure-guided design of a selective BCL-X(L) inhibitor

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Quantitative genetic-interaction mapping in mammalian cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

A comparison of multiple shRNA expression methods for combinatorial RNAi

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Mitochondrial membrane permeabilization in cell death

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21 (Waf1/Cip1) promoter.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Global mapping of the yeast genetic interaction network

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5800952

Enhanced redundancy in Akt and mitogen-activated protein kinase-induced survival of malignant versus normal prostate epithelial cells

10 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNBT.4048

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NBT.4048

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251726%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251726%20AND%20SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

29251726

1 reference