(Q48117853)

8 February 2018

http://europepmc.org/abstract/MED/29240402

title

Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors (English)

1 reference

8 February 2018

http://europepmc.org/abstract/MED/29240402

main subject

Aldehyde dehydrogenase 1 family member A2

1 reference

protein homotetramerization

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Gunda I. Georg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

John K Amory

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Ernst Schönbrunn

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Yan Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Jin-Yi Zhu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Kwon Ho Hong

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

David C Mikles

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Alex S Goldstein

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

publication date

14 December 2017

1 reference

8 February 2018

http://europepmc.org/abstract/MED/29240402

published in

ACS Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

582-590

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

Aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD+ reduction

13 June 2020

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2 November 2018

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2 November 2018

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2 November 2018

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Expression of retinoic acid-metabolizing enzymes, ALDH1A1, ALDH1A2, ALDH1A3, CYP26A1, CYP26B1 and CYP26C1 in canine testis during post-natal development

2 November 2018

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Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

2 November 2018

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2 November 2018

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Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues

2 November 2018

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Pharmacological inhibition of ALDH1A in mice decreases all-trans retinoic acid concentrations in a tissue specific manner

2 November 2018

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Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors

2 November 2018

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Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques

2 November 2018

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Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1

2 November 2018

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N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes

2 November 2018

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Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations

2 November 2018

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Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice.

2 November 2018

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Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility

2 November 2018

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Development of Selective Inhibitors for Aldehyde Dehydrogenases Based on Substituted Indole-2,3-diones

2 November 2018

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Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

2 November 2018

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2 November 2018

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2 November 2018

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Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases

2 November 2018

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Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation

2 November 2018

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Oral administration of a retinoic Acid receptor antagonist reversibly inhibits spermatogenesis in mice

2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase

2 November 2018

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2 November 2018

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2 November 2018

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2 November 2018

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Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase

2 November 2018

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The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity

2 November 2018

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Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate

2 November 2018

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Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide

2 November 2018

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PubMed

12 December 2020

Suppression of spermatogenesis and chronic toxicity in men by a new series of bis(dichloroacetyl) diamines

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PubMed

12 December 2020

Identifying and characterizing binding sites on the irreversible inhibition of human glutathione S-transferase P1-1 by S-thiocarbamoylation

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PubMed

12 December 2020

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12 December 2020

10.1021/ACSCHEMBIO.7B00685

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29240402%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference