(Q48129649)

8 February 2018

title

The transcription factor PU.1 is critical for viability and function of human brain microglia. (English)

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8 February 2018

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6

Richard L M Faull

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8 February 2018

author name string

Amy M Smith

1

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8 February 2018

Hannah M Gibbons

2

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8 February 2018

Robyn L Oldfield

3

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8 February 2018

Peter M Bergin

4

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8 February 2018

Edward W Mee

5

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8 February 2018

Mike Dragunow

7

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8 February 2018

publication date

9 March 2013

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8 February 2018

published in

Glia

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8 February 2018

volume

61

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8 February 2018

page(s)

929-942

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8 February 2018

issue

6

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8 February 2018

PU.1 is a lineage-specific regulator of tyrosine phosphatase CD45.

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PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

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The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1.

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PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells

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Cross-talk between regulators of myeloid development: C/EBPalpha binds and activates the promoter of the PU.1 gene

21 January 2018

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Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

21 January 2018

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The key role of PU.1/SPI-1 in B cells, myeloid cells and macrophages.

21 January 2018

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Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease.

21 January 2018

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A method for generating high-yield enriched neuronal cultures from P19 embryonal carcinoma cells

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MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.

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Microglial cell origin and phenotypes in health and disease

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Valproic acid enhances microglial phagocytosis of amyloid-beta(1-42).

21 January 2018

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Microglial senescence: does the brain's immune system have an expiration date?

21 January 2018

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Microglial activation in presymptomatic Huntington's disease gene carriers

21 January 2018

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Immunohistochemical staining of post-mortem adult human brain sections.

21 January 2018

1 reference

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PU.1 expression in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors.

21 January 2018

1 reference

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Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

Transcriptomic profiling identifies a PU.1 regulatory network in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

PU.1 regulates the CXCR1 promoter

21 January 2018

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Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: uncontrolled inflammation drives disease progression?

21 January 2018

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C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

Comparison of polarization properties of human adult microglia and blood-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

Cellular composition of human glial cultures from adult biopsy brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22486

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7 January 2021

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Identifiers

DOI

10.1002/GLIA.22486

1 reference

8 February 2018

PubMed ID

23483680

1 reference

8 February 2018