(Q48139490)

English

Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

(+-)-flurbiprofen

1 reference

ChEBI release 2020-05-28

Stanley I. Rapoport

5

object named as

Stanley I Rapoport

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

author name string

Mireille Basselin

1

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

Nelly E Villacreses

2

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

Ho-Joo Lee

3

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

Jane M Bell

4

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

publication date

12 June 2007

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

Neurochemical Research

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

32

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

11

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

1857-1867

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

https://scigraph.springernature.com/pub.10.1007/s11064-007-9372-3

0 references

Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism.

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9372-3

21 January 2018

Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats.

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9372-3

21 January 2018

Control of polyunsaturated acids in tissue lipids

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9372-3

21 January 2018

Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9372-3

21 January 2018

In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9372-3

21 January 2018

A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventricles

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenases and the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl est

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central and peripheral mediation of hypothermia, tremor and salivation induced by muscarinic agonists in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad-spectrum cyclooxygenase inhibitor ibuprofen are reversed by increasing endogenous brain-derived neurotrophic factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging brain phospholipase A2 activation in awake rats in response to the 5-HT2A/2C agonist (+/-)2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-localization of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential in vivo incorporation of [3H]arachidonic acid from blood in rat brain synaptosomal fractions before and after cholinergic stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative analysis of simple lipid classes by thin-layer chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acetylsalicylic acid on blood glucose, plasma FFA, glycerol, 3-hydroxybutyrate, alanine, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravenous injection of [1-14C]arachidonate to examine regional brain lipid metabolism in unanesthetized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor binding thermodynamics at the neuronal nicotinic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arecoline-Stimulated Brain Incorporation of Intravenously Administered Fatty Acids in Unanesthetized Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain prostaglandin content in rats sacrificed by decapitation vs focused microwave irradiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Key role for cyclooxygenase-2 in PGE2 and PGF2alpha receptor regulation and cerebral blood flow of the newborn.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NSAID-related psychiatric adverse events: who is at risk?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlation between release of free arachidonic acid and prostaglandin formation in brain cortex and cerebellum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygenase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+-dependent phospholipase A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated formation of eicosanoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain arachidonic acid incorporation and precursor pool specific activity during intravenous infusion of unesterified [3H]arachidonate in the anesthetized rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resting and arecoline-stimulated brain metabolism and signaling involving arachidonic acid are altered in the cyclooxygenase-2 knockout mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Segregated coupling of phospholipases A2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transfected m5 muscarinic acetylcholine receptor stimulates phospholipase A2 by inducing both calcium influx and activation of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of cytoplasmic phospholipase A2 in the normal rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of subcutaneous microdialysis sampling for pharmacokinetic studies of flurbiprofen in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Groups I, II and III extracellular phospholipases A2: selective inhibition of group II enzymes by indomethacin but not other NSAIDs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms for inhibition of free fatty acid mobilization by nicotinic acid and sodium salicylate in canine subcutaneous adipose tissue in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for the isolation and purification of total lipides from animal tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional brain metabolic responsivity to the muscarinic cholinergic agonist arecoline is similar in young and aged Fischer-344 rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of salicylate on plasma nonesterified fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of two non-steroidal anti-inflammatory drugs on lipolysis and on plasma post-heparin lipoprotein lipase activity in normal man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 Extraction of tissue lipids with a solvent of low toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective dopamine receptor stimulation differentially affects [3H]arachidonic acid incorporation, a surrogate marker for phospholipase A2-mediated neurotransmitter signal transduction, in a rodent model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of acute and chronic arecoline treatment on cerebral metabolism and blood flow in the conscious rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delivery and turnover of plasma-derived essential PUFAs in mammalian brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychotropic effects of COX-2 inhibitors--a possible new approach for the treatment of psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acetylsalicylic acid on plasma lipids and on post-heparin lipase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17562170

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-007-9372-3

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/17562170

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