(Q48151677)

9 February 2018

title

Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS. (English)

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9 February 2018

author

Claudia Bagni

5

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9 February 2018

author name string

Laura Trovò

1

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9 February 2018

Tariq Ahmed

2

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9 February 2018

Zsuzsanna Callaerts-Vegh

3

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9 February 2018

Andrea Buzzi

4

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9 February 2018

Marinee Chuah

6

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9 February 2018

Thierry Vandendriessche

7

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9 February 2018

Rudi D'Hooge

8

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9 February 2018

Detlef Balschun

9

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9 February 2018

Carlos G Dotti

10

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9 February 2018

language of work or name

English

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publication date

24 February 2013

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9 February 2018

published in

Nature Neuroscience

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9 February 2018

volume

16

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9 February 2018

issue

4

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9 February 2018

page(s)

449-455

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9 February 2018

https://scigraph.springernature.com/pub.10.1038/nn.3342

exact match

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cites work

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Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

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Fodrin inhibits phospholipases A2, C, and D by decreasing polyphosphoinositide cell content

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Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains.

21 January 2018

1 reference

Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover

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Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation.

21 January 2018

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Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: transgenic rescue and interactions with gene background

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The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.

21 January 2018

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Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro

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Membrane lipids in the aging human brain.

21 January 2018

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MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains.

21 January 2018

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The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells

21 January 2018

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Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism

21 January 2018

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Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

21 January 2018

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Regulation of postsynaptic AMPA responses by synaptojanin 1

21 January 2018

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EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1

21 January 2018

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Coupling exo- and endocytosis: an essential role for PIP₂ at the synapse.

21 January 2018

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Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

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21 January 2018

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A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells

21 January 2018

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Actin filament assembly by myristoylated alanine-rich C kinase substrate-phosphatidylinositol-4,5-diphosphate signaling is critical for dendrite branching

21 January 2018

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GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism

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21 January 2018

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Overexpression of the myristoylated alanine-rich C-kinase substrate inhibits cell adhesion to extracellular matrix components

21 January 2018

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Spred1 is required for synaptic plasticity and hippocampus-dependent learning

21 January 2018

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Applications of the Morris water maze in the study of learning and memory

21 January 2018

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Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning.

21 January 2018

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Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

21 January 2018

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12 December 2020

Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

1 reference

12 December 2020

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D

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12 December 2020

MARCKS, membranes, and calmodulin: kinetics of their interaction

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12 December 2020

The ageing cortical synapse: hallmarks and implications for cognitive decline

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12 December 2020

Membrane lipids of adult human brain: lipid composition of frontal and temporal lobe in subjects of age 20 to 100 years.

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12 December 2020

Identifiers

DOI

10.1038/NN.3342

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9 February 2018

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9 February 2018