(Q48152166)

9 February 2018

title

Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: an application in multiple sclerosis (English)

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9 February 2018

main subject

multiple sclerosis

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phase III clinical trial

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phase II clinical trial

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author

Nigel Stallard

3

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9 February 2018

Nick Parsons

object named as

N Parsons

2

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Tim Friede

object named as

T Friede

1

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author name string

S Todd

4

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9 February 2018

E Valdes Marquez

5

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J Chataway

6

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R Nicholas

7

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9 February 2018

language of work or name

English

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publication date

22 February 2011

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9 February 2018

published in

Statistics in Medicine

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9 February 2018

volume

30

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issue

13

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9 February 2018

page(s)

1528-1540

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9 February 2018

A two-stage design for choosing among several experimental treatments and a control in clinical trials

cites work

1 reference

Sequential designs for phase III clinical trials incorporating treatment selection

21 January 2018

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Testing and estimation in flexible group sequential designs with adaptive treatment selection

21 January 2018

1 reference

Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: general concepts

21 January 2018

1 reference

Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)

21 January 2018

1 reference

Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis

21 January 2018

1 reference

The measurement and clinical relevance of brain atrophy in multiple sclerosis

21 January 2018

1 reference

Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

21 January 2018

1 reference

Interim monitoring of clinical trials based on long-term binary endpoints

21 January 2018

1 reference

Seamlessly expanding a randomized phase II trial to phase III.

21 January 2018

1 reference

On closed testing procedures with special reference to ordered analysis of variance

21 January 2018

1 reference

Evaluation of experiments with adaptive interim analyses.

21 January 2018

1 reference

Adaptive sample size calculations in group sequential trials

21 January 2018

1 reference

Confirmatory adaptive designs with Bayesian decision tools for a targeted therapy in oncology

21 January 2018

1 reference

MRI T2 lesion burden in multiple sclerosis: a plateauing relationship with clinical disability.

21 January 2018

1 reference

Monitoring pairwise comparisons in multi-armed clinical trials.

21 January 2018

1 reference

What should be the role of homogeneity testing in adaptive trials?

21 January 2018

1 reference

Exploring changes in treatment effects across design stages in adaptive trials.

21 January 2018

1 reference

A Multiple Comparison Procedure for Comparing Several Treatments with a Control

21 January 2018

1 reference

Adaptive Dunnett tests for treatment selection

21 January 2018

1 reference

A group-sequential design for clinical trials with treatment selection

21 January 2018

1 reference

A Comparison of Methods for Adaptive Treatment Selection

21 January 2018

1 reference

Recursive Combination Tests

21 January 2018

1 reference

An Adaptive Group Sequential Design for Phase II/III Clinical Trials that Select a Single Treatment From Several

21 January 2018

1 reference

A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/SIM.4202

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9 February 2018

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9 February 2018