(Q48157530)

9 February 2018

title

Exposure to pyrithiamine increases β-amyloid accumulation, Tau hyperphosphorylation, and glycogen synthase kinase-3 activity in the brain (English)

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9 February 2018

main subject

pyrithiamine bromide

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ChEBI release 2020-05-28

Jing Zhao

1

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9 February 2018

Xiaojing Sun

2

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9 February 2018

Zhe Yu

3

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9 February 2018

Xiaoli Pan

4

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9 February 2018

Fenghua Gu

5

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9 February 2018

Jia Chen

6

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9 February 2018

Wenxin Dong

7

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9 February 2018

Lei Zhao

8

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9 February 2018

Chunjiu Zhong

9

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9 February 2018

publication date

22 June 2010

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9 February 2018

published in

Neurotoxicity Research

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9 February 2018

volume

19

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9 February 2018

issue

4

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9 February 2018

page(s)

575-583

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9 February 2018

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

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Pyrithiamine as a substrate for thiamine pyrophosphokinase

21 January 2018

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Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

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Brain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease

21 January 2018

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Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

21 January 2018

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Brain mitochondrial metabolism in experimental thiamine deficiency.

21 January 2018

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

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Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

21 January 2018

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Development of Wernicke-Korsakoff syndrome after long intervals following gastrectomy

21 January 2018

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Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

21 January 2018

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Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

21 January 2018

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Decreased transketolase activity contributes to impaired hippocampal neurogenesis induced by thiamine deficiency

21 January 2018

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Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease

21 January 2018

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21 January 2018

12 December 2020

Judging a protein by more than its name: GSK-3.

1 reference

12 December 2020

Is thiamine deficiency in elderly people related to age or co-morbidity?

1 reference

12 December 2020

Thiamine deficiency after feeding pyrithiamine

1 reference

12 December 2020

The mode of action of pyrithiamine as an inductor of thiamine deficiency

1 reference

12 December 2020

Low energy levels in thiamine-deficient encephalopathy.

1 reference

12 December 2020

Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.

1 reference

12 December 2020

Reduced concentrations of several vitamins in normal weight patients with late-onset dementia of the Alzheimer type without vascular disease.

1 reference

12 December 2020

Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

1 reference

12 December 2020

Molecular cloning and expression of glycogen synthase kinase-3/factor A

1 reference

12 December 2020

GSK-3 is essential in the pathogenesis of Alzheimer's disease.

1 reference

12 December 2020

Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides

1 reference

12 December 2020

10.1007/S12640-010-9204-0

Identifiers

DOI

1 reference

9 February 2018

1 reference

9 February 2018