(Q35207622)

7 August 2017

1 reference

title

Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment (English)

1 reference

7 August 2017

1 reference

1 reference

Hagit Eldar-Finkelman

series ordinal

1

object named as

Hagit Eldar-Finkelman

1 reference

7 August 2017

Ronit Ilouz

2

1 reference

PubMed ID

12943495

7 August 2017

language of work or name

English

0 references

publication date

1 September 2003

1 reference

Expert Opinion on Investigational Drugs

7 August 2017

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7 August 2017

12

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7 August 2017

1511-1519

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7 August 2017

9

1 reference

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

7 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Insulin signaling pathways in time and space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

cDNA cloning and properties of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Glycogen synthase kinase 3: an emerging therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Structure of GSK3beta reveals a primed phosphorylation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3beta and Shaggy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

A template for the protein kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Protein kinase inhibition: natural and synthetic variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Structural biology in drug design: selective protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Conformational diversity of catalytic cores of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Strategies toward the design of novel and selective protein tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Designing bisubstrate analog inhibitors for protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Anti-bipolar therapy: mechanism of action of lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

A molecular mechanism for the effect of lithium on development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Peptide-mediated cell delivery: application in protein target validation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Noninvasive intracellular delivery of functional peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Alternative routes of administration as an approach to improve insulin therapy: update on dermal, oral, nasal and pulmonary insulin delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Delivery of bioactive peptides and proteins across oral (buccal) mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Albumin binding as a general strategy for improving the pharmacokinetics of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.9.1511

10.1517/13543784.12.9.1511

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12943495