(Q48167130)

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Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

apoptotic process

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author name string

J Tohyama

1

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

Y Oya

2

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

T Ezoe

3

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

M T Vanier

4

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

H Nakayasu

5

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

N Fujita

6

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

K Suzuki

7

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

publication date

1 June 1999

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

Journal of Inherited Metabolic Disease

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

22

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

5

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

649-662

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of cerebroside sulphate and subcellular distribution of its metabolites in cultured skin fibroblasts derived from controls, metachromatic leukodystrophy, globoid cell leukodystrophy and Farber disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts.

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of prosaposin as a neurotrophic factor

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite effects of tumor necrosis factor alpha on the sphingomyelin-ceramide pathway in two myeloid leukemia cell lines: role of transverse sphingomyelin distribution in the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of lysosomal acid ceramidase in the metabolism of ceramide in human skin fibroblasts

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

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Genetic analysis of control of proliferation in fibroblastic cells in culture. I. Isolation and characterization of mutants temperature-sensitive for proliferation or survival of untransformed diploid rat cell line 3Y1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

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Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their common gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

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(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

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Modulation of cell growth and differentiation by ceramide

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the neurotrophic factor sequence of prosaposin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death induced by ceramide

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https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

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Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphi

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assignment of the gene for human sphingolipid activator protein-2 (SAP-2) to chromosome 10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by prosaposin against ischemia-induced learning disability and neuronal loss.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prosaposin facilitates sciatic nerve regeneration in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: biochemical signs of combined sphingolipidoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patient cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of ceramide-containing endocytotic vesicles in human diploid fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis involved in density-dependent regulation of rat fibroblastic 3Y1 cell culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of ceramide production confers resistance to radiation-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide induces apoptosis in cultured mesencephalic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional biochemical findings in a patient and fetal sibling with a genetic defect in the sphingolipid activator protein (SAP) precursor, prosaposin. Evidence for a deficiency in SAP-1 and for a normal lysosomal neuraminidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis of metachromatic leukodystrophy, Krabbe disease, and Farber disease after uptake of fatty acid-labeled cerebroside sulfate into cultured skin fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Farber's lipogranulomatosis. Report of a case and demonstration of an excess of free ceramide and ganglioside

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingolipid activator protein D (sap-D) stimulates the lysosomal degradation of ceramide in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family with combined Farber and Sandhoff, isolated Sandhoff and isolated fetal Farber disease: postnatal exclusion and prenatal diagnosis of Farber disease using lipid loading tests on intact cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ceramide in cellular senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gene coding for a sphingolipid activator protein, SAP-1, is on human chromosome 10

1 reference

https://pubmed.ncbi.nlm.nih.gov/10399097

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1005590316064

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/10399097

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