(Q48193936)

English

Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

scientific article published on 18 May 2010

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine (English)

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

2

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Michael Sørensen

5

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Helle S. Waagepetersen

12

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Hendrik Vilstrup

7

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Hendrik Vilstrup

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Susanne Keiding

6

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Susanne Keiding

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

11

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Arne Schousboe

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Ursula Sonnewald

10

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Ursula Sonnewald

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

1

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Renata Leke

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Luis Eugenio Portela Fernandes de Souza

9

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Luis V Portela

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

4

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Torun M Melø

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

author name string

Malene Anker

3

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Peter Ott

8

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

publication date

18 May 2010

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Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Neurotoxicity Research

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

19

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

3

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

496-510

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint

1 reference

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The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy

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21 January 2018

Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome.

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21 January 2018

Activity of the lactate-alanine shuttle is independent of glutamate-glutamine cycle activity in cerebellar neuronal-astrocytic cultures.

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21 January 2018

Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons

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21 January 2018

Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia.

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21 January 2018

The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma

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21 January 2018

Hepatic Encephalopathy.

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21 January 2018

Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation

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21 January 2018

Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems

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21 January 2018

Pathophysiology of hepatic encephalopathy: a new look at ammonia

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21 January 2018

Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex

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21 January 2018

Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

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21 January 2018

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

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21 January 2018

Role of glutamine in cerebral nitrogen metabolism and ammonia neurotoxicity

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21 January 2018

Cerebral ammonia metabolism in hyperammonemic rats

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21 January 2018

Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain

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21 January 2018

Hepatic encephalopathy: An update of pathophysiologic mechanisms

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21 January 2018

Energy metabolism in brain cells: effects of elevated ammonia concentrations

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21 January 2018

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts

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21 January 2018

Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy

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21 January 2018

Glutamine-induced free radical production in cultured astrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Glutamine in the mechanism of ammonia-induced astrocyte swelling

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21 January 2018

Potential mechanisms of enhanced GABA-mediated inhibitory neurotransmission in liver failure

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21 January 2018

Ammonia effects on pyruvate/lactate production in astrocytes--interaction with glutamate

1 reference

https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Partial pressure of ammonia versus ammonia in hepatic encephalopathy.

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https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Evaluation of plasma ammonia levels in patients with acute liver failure and chronic liver disease and its correlation with the severity of hepatic encephalopathy and clinical features of raised intracranial tension

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21 January 2018

Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

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21 January 2018

Demonstration of neuron-glia transfer of precursors for GABA biosynthesis in a co-culture system of dissociated mouse cerebral cortex

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https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Blood ammonia levels and hepatic encephalopathy

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https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

[1-13C]glucose metabolism in brain cells: isotopomer analysis of glutamine from cerebellar astrocytes and glutamate from granule cells.

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https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Ammonia-induced production of free radicals in primary cultures of rat astrocytes

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21 January 2018

Astroglial dysfunction in hepatic encephalopathy

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21 January 2018

Fine structural localization of glutamine synthetase in astrocytes of rat brain

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https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Mechanisms of ammonia-induced astrocyte swelling

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21 January 2018

Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis

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21 January 2018

The relative significance of CO2-fixing enzymes in the metabolism of rat brain

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21 January 2018

Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine

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21 January 2018

Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia

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https://api.crossref.org/works/10.1007%2FS12640-010-9198-7

21 January 2018

In vitro and in vivo effects of ammonia on glucose metabolism in the astrocytes of rat cerebral cortex

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21 January 2018

Response of rat cerebral glycolytic enzymes to hyperammonemic states

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21 January 2018

GABA: homeostatic and pharmacological aspects

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21 January 2018

Pyruvate carboxylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

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21 January 2018

Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats

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Monitoring extracellular concentrations of lactate, glutamate, and glycerol by in vivo microdialysis in the brain during liver transplantation in acute liver failure

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Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

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Pyruvate carboxylase activity in primary cultures of astrocytes and neurons

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Precursors of glutamic acid nitrogen in primary neuronal cultures: studies with 15N.

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21 January 2018

The anaplerotic flux and ammonia detoxification in hepatic encephalopathy

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21 January 2018

An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: further studies using NMR spectroscopy

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Ammonia toxicity under hyponatremic conditions in astrocytes: de novo synthesis of amino acids for the osmoregulatory response

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21 January 2018

Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study

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The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

1 reference

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21 January 2018

Glial-neuronal interactions as studied by cerebral metabolism of [2-13C]acetate and [1-13C]glucose: an ex vivo 13C NMR spectroscopic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes: glutamate producers for neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemistry and physiology of brain ammonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of metabolic compartmentation in hyperammonemic brain by natural abundance 13C-NMR detection of 13C-15N coupling patterns and isotopic shifts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the blood-brain barrier and its role in the transport of amino acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic fate of 13N-labeled ammonia in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct and indirect enhancement of GABAergic neurotransmission by ammonia: implications for the pathogenesis of hyperammonemic syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multinuclear NMR spectroscopy studies on NH4Cl-induced metabolic alterations and detoxification processes in primary astrocytes and glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic compartments in vivo. Ammonia and glutamic acid metabolism in brain and liver.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal regulation of glutamate transporter subtype expression in astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMR spectroscopic study on the metabolic fate of [3-(13)C]alanine in astrocytes, neurons, and cocultures: implications for glia-neuron interactions in neurotransmitter metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20480276

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12640-010-9198-7

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 February 2018

http://europepmc.org/abstract/MED/20480276

ResearchGate publication ID

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