(Q48199015)

9 February 2018

title

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. (English)

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9 February 2018

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Ted M Dawson

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9 February 2018

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John Q Trojanowski

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9 February 2018

author name string

Aaron C Pawlyk

1

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9 February 2018

Benoit I Giasson

2

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9 February 2018

Deepak M Sampathu

3

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9 February 2018

Francisco A Perez

4

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9 February 2018

Kah Leong Lim

5

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9 February 2018

Valina L Dawson

6

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9 February 2018

Richard D Palmiter

8

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9 February 2018

Virginia M-Y Lee

10

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language of work or name

English

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publication date

12 September 2003

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9 February 2018

Journal of Biological Chemistry

published in

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9 February 2018

volume

278

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9 February 2018

page(s)

48120-48128

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9 February 2018

issue

48

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9 February 2018

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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TRIADs: a new class of proteins with a novel cysteine-rich signature

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Complex relationship between Parkin mutations and Parkinson disease

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CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

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Cloning of rat parkin cDNA and distribution of parkin in rat brain

21 January 2018

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Spatial distribution, cellular integration and stage development of Parkin protein in Xenopus brain

21 January 2018

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Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies

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Differential expression and tissue distribution of parkin isoforms during mouse development

21 January 2018

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Parkin is associated with cellular vesicles

21 January 2018

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Co-association of parkin and alpha-synuclein

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

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Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

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Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

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Parkin immunoreactivity in the brain of human and non-human primates: an immunohistochemical analysis in normal conditions and in Parkinsonian syndromes

21 January 2018

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Characterization of parkin in bovine peripheral nerve.

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

21 January 2018

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Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam

21 January 2018

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21 January 2018

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The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans

21 January 2018

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Widespread alterations of alpha-synuclein in multiple system atrophy

21 January 2018

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Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology

21 January 2018

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Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes

21 January 2018

1 reference

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Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop

21 January 2018

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Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

21 January 2018

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Regional and cellular expression of the parkin gene in the rat cerebral cortex

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M306889200

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9 February 2018

PubMed ID

12972409

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9 February 2018