(Q48207430)

9 February 2018

http://europepmc.org/abstract/MED/29191911

title

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. (English)

1 reference

9 February 2018

http://europepmc.org/abstract/MED/29191911

main subject

Protein kinase MEC1 YBR136W

1 reference

GOA release 2020-03-11

Lcd1p YDR499W

1 reference

GOA release 2020-03-11

author

Gang Cai

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Xuejuan Wang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Tingting Ran

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Weiwu Wang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Xuan Zhang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Jiyu Xin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Zhihui Zhang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Tengwei Wu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

language of work or name

English

0 references

publication date

1 December 2017

1 reference

9 February 2018

http://europepmc.org/abstract/MED/29191911

published in

Science

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

358

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

6367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

1206-1209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29191911%20AND%20SRC:MED&resulttype=core&format=json

ATR and ATRIP: partners in checkpoint signaling

11 June 2020

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The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization

21 January 2018

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Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forks

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21 January 2018

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Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

21 January 2018

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Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase

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ATR autophosphorylation as a molecular switch for checkpoint activation.

21 January 2018

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Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex

21 January 2018

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Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo

21 January 2018

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

21 January 2018

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Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism

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TopBP1 activates the ATR-ATRIP complex

21 January 2018

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Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase

21 January 2018

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Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase

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Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway

21 January 2018

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Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

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The structural basis for mTOR function

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Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.

21 January 2018

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The unstructured C-terminal tail of yeast Dpb11 (human TopBP1) protein is dispensable for DNA replication and the S phase checkpoint but required for the G2/M checkpoint.

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ETAA1 acts at stalled replication forks to maintain genome integrity

21 January 2018

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Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

21 January 2018

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21 January 2018

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