(Q45967119)

18 December 2017

title

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. (English)

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18 December 2017

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Akiko Kumagai

1

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18 December 2017

Soo-Mi Kim

series ordinal

2

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18 December 2017

William G Dunphy

series ordinal

3

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18 December 2017

language of work or name

English

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publication date

15 September 2004

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18 December 2017

Journal of Biological Chemistry

published in

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18 December 2017

volume

279

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18 December 2017

issue

48

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18 December 2017

page(s)

49599-49608

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18 December 2017

A unified view of the DNA-damage checkpoint

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

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Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

21 January 2018

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Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

21 January 2018

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Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

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Mrc1 transduces signals of DNA replication stress to activate Rad53.

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Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

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Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

21 January 2018

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

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21 January 2018

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The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint

21 January 2018

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

21 January 2018

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21 January 2018

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A novel protein activity mediates DNA binding of an ATR-ATRIP complex

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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Human claspin is required for replication checkpoint control

21 January 2018

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Regulation of checkpoint kinases through dynamic interaction with Crb2.

21 January 2018

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The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

21 January 2018

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Activation of Xenopus Chk1 by mutagenesis of threonine-377.

21 January 2018

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Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes

21 January 2018

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Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408353200

21 January 2018

Identifiers

DOI

10.1074/JBC.M408353200

1 reference

18 December 2017

1 reference

18 December 2017