(Q48227806)

http://europepmc.org/abstract/PMC/5774632

9 February 2018

title

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion. (English)

1 reference

http://europepmc.org/abstract/PMC/5774632

9 February 2018

1 reference

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Shenghui He

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jessica A Sorrentino

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

John E Bisi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Renger G Tiessen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Karenann M Makhuli

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

William A Wargin

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Henko Tadema

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Rajesh Malik

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Patrick J Roberts

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Hannah Storrie-White

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Ewoud-Jan van Hoogdalem

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Jay C Strum

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

1 April 2017

1 reference

http://europepmc.org/abstract/PMC/5774632

9 February 2018

published in

Science Translational Medicine

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

387

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28446688%20AND%20SRC:MED&resulttype=core&format=json

Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression

7 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Cyclin-Dependent Kinase 4/6 Inhibitors for the Treatment of Breast Cancer: A Review of Preclinical and Clinical Data

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The Role of CDK4/6 Inhibition in Breast Cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The history and future of targeting cyclin-dependent kinases in cancer therapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Comprehensive molecular characterization of urothelial bladder carcinoma

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Aging of the hematopoietic system

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Comprehensive molecular portraits of human breast tumours

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Systematic identification of genomic markers of drug sensitivity in cancer cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Stem cells and the aging hematopoietic system

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Integrative genomic profiling of human prostate cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Acute myeloid leukemia or myelodysplastic syndrome in randomized controlled clinical trials of cancer chemotherapy with granulocyte colony-stimulating factor: a systematic review

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Mechanisms of hematopoietic stem cell aging

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

A chemical method for fast and sensitive detection of DNA synthesis in vivo

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Cell intrinsic alterations underlie hematopoietic stem cell aging.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

5-Fluorouracil: mechanisms of action and clinical strategies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Exploiting cancer cell cycling for selective protection of normal cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Long term hematopoietic damage after chemotherapy and cytokine

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The aging of hematopoietic stem cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The impact of dose intensity of standard chemotherapy regimens in extensive stage small cell lung cancer.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Ways of minimising hematopoietic damage induced by radiation and cytostatic drugs--the possible role of inhibitors

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Hematopoietic stem cell depletion by restorative growth factor regimens during repeated high-dose cyclophosphamide therapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

The effect of immunosuppressive chemotherapy on immune function in patients with malignant disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Mouse development and cell proliferation in the absence of D-cyclins.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Most primitive hematopoietic stem cells are stimulated to cycle rapidly after treatment with 5-fluorouracil.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Update on adjuvant chemotherapy for early breast cancer

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5774632

Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence

2 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAL3986

Assessing permanent damage to primitive hematopoietic stem cells after chemotherapy using the competitive repopulation assay

21 January 2018

1 reference

12 December 2020

Cyclin E overexpression and amplification in human tumours

1 reference

12 December 2020

5-Fluorouracil spares hemopoietic stem cells responsible for long-term repopulation

1 reference

12 December 2020

Does stem cell exhaustion result from combining hematopoietic growth factors with chemotherapy? If so, how do we prevent it?

1 reference

12 December 2020

Prophylactic pretreatment of mice with hematopoietic growth factors induces expansion of primitive cell compartments and results in protection against 5-fluorouracil-induced toxicity

1 reference

12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

12 December 2020

Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma

1 reference

12 December 2020

10.1126/SCITRANSLMED.AAL3986

Identifiers

DOI

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lnd7n6f3srdpbetazfofaz7xa4

30 July 2022

release_lnd7n6f3srdpbetazfofaz7xa4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lnd7n6f3srdpbetazfofaz7xa4

30 July 2022

https://api.fatcat.wiki/v0/release/lnd7n6f3srdpbetazfofaz7xa4

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/lnd7n6f3srdpbetazfofaz7xa4

1 reference

30 July 2022