(Q48250731)

English

3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

scientific article published in March 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17344409%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism (English)

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Europe PubMed Central

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26 December 2019

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Annika Thorsell

3

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26 December 2019

Roberto Ciccocioppo

13

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Roberto Ciccocioppo

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26 December 2019

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Donald R Gehlert

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26 December 2019

Andrea Cippitelli

2

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26 December 2019

Anh Dzung Lê

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26 December 2019

Philip A Hipskind

5

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26 December 2019

Chafiq Hamdouchi

6

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26 December 2019

Jianliang Lu

7

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26 December 2019

Erik J Hembre

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26 December 2019

Jeffrey Cramer

9

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26 December 2019

Min Song

10

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26 December 2019

David McKinzie

11

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26 December 2019

Michelle Morin

12

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26 December 2019

Markus Heilig

14

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26 December 2019

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publication date

1 March 2007

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26 December 2019

Journal of Neuroscience

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26 December 2019

27

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26 December 2019

10

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26 December 2019

2718-2726

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Europe PubMed Central

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26 December 2019

Understanding corticotropin releasing factor neurobiology: contributions from mutant mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excessive ethanol drinking following a history of dependence: animal model of allostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of corticotropin-releasing factor in drug addiction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Bi

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist. II.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of physical dependence upon ethanol and the associated behavioral changes in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Getting closer to affective disorders: the role of CRH receptor systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic characterization of genetically selected Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of chlorpromazine and imipramine in adipose and other tissues of rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17344409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4985-06.2007

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17344409%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17344409%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17344409%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

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