(Q48256985)

10 February 2018

title

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity (English)

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10 February 2018

2

D J Greenblatt

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10 February 2018

author name string

R M Arendt

1

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10 February 2018

D C Liebisch

3

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10 February 2018

M D Luu

4

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10 February 2018

S M Paul

5

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10 February 2018

publication date

1 January 1987

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10 February 2018

published in

Psychopharmacology

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10 February 2018

volume

93

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10 February 2018

issue

1

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10 February 2018

page(s)

72-76

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10 February 2018

Prolonged accumulation of diazepam in obesity.

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02439589

Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FBF02439589

Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics

21 January 2018

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12 December 2020

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

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IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTION

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Entry of diazepam and its major matabolite into cerebrospinal fluid.

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12 December 2020

Benzodiazepine receptors in the central nervous system

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Importance of protein binding for the interpretation of serum or plasma drug concentrations

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Comparison of benzodiazepine receptor binding in membranes from human or rat brain.

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A practical computer-based approach to the analysis of radioligand binding experiments

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Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.

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The benzodiazepine receptor. An update

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Brain receptor binding and lipophilic character of benzodiazepines

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Reduced single-dose clearance of clobazam in elderly men predicts increased multiple-dose accumulation

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Drug therapy. Current status of benzodiazepines

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Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam

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Clinical importance of the interaction of diazepam and cimetidine.

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Midazolam: pharmacology and uses

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Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats.

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12 December 2020

Benzodiazepine receptor binding: influence of physiologic and pharmacologic factors

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12 December 2020

Electron-capture GLC determination of clobazam and desmethylclobazam in plasma

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Quantitation by gas chromatography of the 1- and 4-hydroxy metabolites of midazolam in human plasma.

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Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects

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12 December 2020

In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution

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12 December 2020

Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.

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12 December 2020

Automated gas chromatographic determination of plasma alprazolam concentrations

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12 December 2020

Concentration-independent plasma protein binding of benzodiazepines

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12 December 2020

Single and multiple dose kinetics of clobazam, and clinical effects during multiple dosage

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12 December 2020

Automated Electron-Capture Gas Chromatographic Analysis of Flunitrazepam in Plasma

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12 December 2020

Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam

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12 December 2020

Identifiers

DOI

10.1007/BF02439589

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10 February 2018

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Fatcat ID

0 references

1 reference

10 February 2018