(Q48273082)

http://europepmc.org/abstract/MED/23197721

10 February 2018

title

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. (English)

1 reference

http://europepmc.org/abstract/MED/23197721

10 February 2018

0 references

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Urban Lendahl

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Santiago Parpal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Anders Juréus

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Helena Karlström

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

author name string

Tomas Borgegård

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Susanne Gustavsson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Charlotte Nilsson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Rebecka Klintenberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Anna-Lena Berg

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Susanne Rosqvist

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Lutgarde Serneels

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Samuel Svensson

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Fredrik Olsson

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Shaobo Jin

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Hongmei Yan

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Johanna Wanngren

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Anna Ridderstad-Wollberg

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Patrik Wollberg

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Kenneth Stockling

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Asa Malmberg

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Johan Lund

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Johan Lundkvist

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

Bart De Strooper

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

1 November 2012

1 reference

http://europepmc.org/abstract/MED/23197721

10 February 2018

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

issue

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

page(s)

17297-17305

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

15 May 2020

cites work

1 reference

12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

12 December 2020

Gamma -secretase inhibitors repress thymocyte development

1 reference

12 December 2020

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

1 reference

12 December 2020

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

12 December 2020

Notch regulation of lymphocyte development and function.

1 reference

12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

12 December 2020

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

1 reference

12 December 2020

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

1 reference

12 December 2020

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

1 reference

12 December 2020

Notch signals control the fate of immature progenitor cells in the intestine

1 reference

12 December 2020

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity

1 reference

12 December 2020

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors

1 reference

12 December 2020

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

1 reference

12 December 2020

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

1 reference

12 December 2020

The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

1 reference

12 December 2020

Identification of gamma-secretase inhibitor potency determinants on presenilin

1 reference

12 December 2020

Intramembrane proteolysis by gamma-secretase

1 reference

12 December 2020

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

1 reference

12 December 2020

Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

1 reference

12 December 2020

The many substrates of presenilin/γ-secretase

1 reference

12 December 2020

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes

1 reference

12 December 2020

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

1 reference

12 December 2020

First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms

1 reference

12 December 2020

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

1 reference

12 December 2020

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

10.1523/JNEUROSCI.1451-12.2012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

release_o2nzc5lgv5bovgkognad37e2fu

15 May 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/o2nzc5lgv5bovgkognad37e2fu

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6621836&resulttype=core&format=json