(Q48283410)

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A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum.

scientific article published on 11 September 2002

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scholarly article

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Europe PubMed Central

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13 November 2019

A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12228250%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

Acremonium chrysogenum

object named as

Acremonium chrysogenum

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inferred from title

Santiago Gutierrez

5

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13 November 2019

Javier Casqueiro

2

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13 November 2019

Francisco Fernandez

4

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13 November 2019

author name string

Ricardo V Ullan

1

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13 November 2019

Oscar Banuelos

3

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13 November 2019

Juan F Martin

6

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13 November 2019

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11 September 2002

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13 November 2019

Journal of Biological Chemistry

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13 November 2019

277

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13 November 2019

46216-46225

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13 November 2019

48

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13 November 2019

Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region

1 reference

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21 January 2018

Biosynthesis and molecular genetics of cephamycins. Cephamycins produced by actinomycetes

1 reference

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21 January 2018

1 reference

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Isolation, sequence determination and expression in Escherichia coli of the isopenicillin N synthetase gene from Cephalosporium acremonium

1 reference

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21 January 2018

Gene organization and plasticity of the beta-lactam genes in different filamentous fungi

1 reference

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21 January 2018

Analysis of the role of cysteine residues in isopenicillin N synthetase activity by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits

1 reference

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21 January 2018

Cell-free conversion of δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium

1 reference

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21 January 2018

Cell-free conversion of isopenicillin N into deacetoxycephalosporin C by Cephalosporium acremonium mutant M-0198.

1 reference

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21 January 2018

Conversion of isopenicillin N into penicillin N in cell-free extracts of Cephalosporium acremonium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus

1 reference

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21 January 2018

Characterization and expression in Streptomyces lividans of cefD and cefE genes from Nocardia lactamdurans: the organization of the cephamycin gene cluster differs from that in Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Functional elements in the promoter region of the Aspergillus nidulans gpdA gene encoding glyceraldehyde-3-phosphate dehydrogenase.

1 reference

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21 January 2018

Transcription of the pcbAB, pcbC and penDE genes of Penicillium chrysogenum AS-P-78 is repressed by glucose and the repression is not reversed by alkaline pHs.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

A moderate amplification of the mecB gene encoding cystathionine-gamma-lyase stimulates cephalosporin biosynthesis in Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate-forming enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1 reference

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21 January 2018

Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the c

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

A nonribosomal system of peptide biosynthesis

1 reference

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21 January 2018

A eukaryotic alanine racemase gene involved in cyclic peptide biosynthesis.

1 reference

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Purification and properties of an alpha-methylacyl-CoA racemase from rat liver

1 reference

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21 January 2018

Purification and characterization of an alpha-methylacyl-CoA racemase from human liver

1 reference

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21 January 2018

Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase

1 reference

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21 January 2018

Stereochemistry of peroxisomal and mitochondrial beta-oxidation of alpha-methylacyl-CoAs

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21 January 2018

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

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21 January 2018

Purification and characterization of the isopenicillin N epimerase from Nocardia lactamdurans

1 reference

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21 January 2018

Chiral inversion of 2-arylpropionic acid non-steroidal anti-inflammatory drugs—II Racemization and hydrolysis of (R)- and (S)-ibuprofen-CoA thioesters

1 reference

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21 January 2018

New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis

1 reference

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21 January 2018

Partial purification and characterization of isopenicillin N epimerase activity from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M207482200

21 January 2018

Expression of the penDE gene of Penicillium chrysogenum encoding isopenicillin N acyltransferase in Cephalosporium acremonium: production of benzylpenicillin by the transformants

1 reference

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21 January 2018

High performance liquid chromatography (HPLC) of natural products V. The use of HPLC in the cell-free biosynthetic conversion of alpha-aminoadipyl-cysteinyl-valine (LLD) into isopenicillin N

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The occurrence of diastereomers of phytanic and pristanic acids and their determination by gas-liquid chromatography

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Accumulation of phytanic acid alpha-oxidation intermediates in Zellweger fibroblasts

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21 January 2018

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