(Q48306498)

English

Amyloid β-Protein Stimulates the Expression of Urokinase-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Human Cerebrovascular Smooth Muscle Cells

scientific article published on May 23, 2003

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scholarly article

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

Amyloid β-Protein Stimulates the Expression of Urokinase-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Human Cerebrovascular Smooth Muscle Cells (English)

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1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12754271

3 January 2024

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10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

author name string

Judianne Davis

1

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

Weibing Zhang

3

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

Feng Xu

4

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

Matthew R. Wagner

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12754271

3 January 2024

William E. Van Nostrand

5

1 reference

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3 January 2024

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publication date

1 May 2003

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Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

23 May 2003

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12754271

3 January 2024

full work available at URL

http://www.jbc.org/article/S0021925820801276/pdf

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12754271

3 January 2024

https://api.elsevier.com/content/article/PII:S0021925820801276?httpAccept=text/xml

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

https://api.elsevier.com/content/article/PII:S0021925820801276?httpAccept=text/plain

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M301398200

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

278

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

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http://europepmc.org/abstract/MED/12754271

19054-19061

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

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21 January 2018

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Amyloid beta-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Amyloid beta-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

In vitro stimulation of tissue-type plasminogen activator by Alzheimer amyloid β-peptide analogues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

The plasminogen activator/plasmin system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Urokinase-type plasminogen activator inhibits amyloid-beta neurotoxicity and fibrillogenesis via plasminogen.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Urokinase and urokinase receptor: a paracrine/autocrine system regulating cell migration and invasiveness

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Proteolytic processing of the 72,000-Da type IV collagenase by urokinase plasminogen activator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

The plasminogen activation system in tumor growth, invasion, and metastasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Cerebrovascular disease is a major factor in the failure of elimination of Abeta from the aging human brain: implications for therapy of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Cerebral amyloid angiopathy: a significant cause of cerebellar as well as lobar cerebral hemorrhage in the elderly.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Clinical features and pathogenesis of intracerebral hemorrhage after rt-PA and heparin therapy for acute myocardial infarction: the Thrombolysis in Myocardial Infarction (TIMI) II Pilot and Randomized Clinical Trial combined experience

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Antibodies to the beta-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Local variation in expression of pro- and antithrombotic factors in vascular endothelium of human autopsy brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Pathogenic effects of D23N Iowa mutant amyloid beta -protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Sympathectomy decreases and adrenergic stimulation increases the release of tissue plasminogen activator (t-PA) from blood vessels: functional evidence for a neurologic regulation of plasmin production within vessel walls and other tissue matrices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301398200

21 January 2018

Alzheimer's disease: genes, proteins, and therapy

1

1 reference

10.1074/JBC.M301398200

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3 January 2024

Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies

19

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells

20

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

The plasmin system is induced by and degrades amyloid-beta aggregates

30

1 reference

10.1074/JBC.M301398200

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3 January 2024

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

34

1 reference

10.1074/JBC.M301398200

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3 January 2024

Cerebral amyloid angiopathy: an overview

50

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

Risk for intracranial hemorrhage after tissue plasminogen activator treatment for acute myocardial infarction. Participants in the National Registry of Myocardial Infarction 2.

52

1 reference

10.1074/JBC.M301398200

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3 January 2024

Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt

55

1 reference

10.1074/JBC.M301398200

https://api.crossref.org/works/10.1074/JBC.M301398200

3 January 2024

Identifiers

10.1074/JBC.M301398200

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

1 reference

Europe PubMed Central

10 February 2018

http://europepmc.org/abstract/MED/12754271

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