(Q48311590)

English

Promoter Hypermethylation of the DNA Repair Gene O6‐Methylguanine‐DNA Methyltransferase is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas

scientific article published on April 1, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

Promoter Hypermethylation of the DNA Repair Gene O6‐Methylguanine‐DNA Methyltransferase is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas (English)

reason for preferred rank

most precise value

1 reference

10.1111/J.1750-3639.2003.TB00017.X

https://api.crossref.org/works/10.1111/J.1750-3639.2003.TB00017.X

1 January 2024

Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744471

1 January 2024

0 references

hypermethylation

1 reference

based on heuristic

inferred from title

DNA methylation

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744471

1 January 2024

4

object named as

Atsuo Yoshino

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

author name string

Chiaki Komine

1

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

Takao Watanabe

2

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

Yoichi Katayama

3

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

Takakazu Yokoyama

5

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

Takao Fukushima

6

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12744471

1 January 2024

publication date

1 April 2003

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095943

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744471

1 January 2024

https://europepmc.org/articles/PMC8095943

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744471

1 January 2024

https://europepmc.org/articles/PMC8095943?pdf=render

Portable Document Format

online access status

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Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744471

1 January 2024

https://doi.org/10.1111/j.1750-3639.2003.tb00017.x

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12744471

1 January 2024

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1750-3639.2003.tb00017.x

1 reference

10.1111/J.1750-3639.2003.TB00017.X

https://api.crossref.org/works/10.1111/J.1750-3639.2003.TB00017.X

1 January 2024

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1750-3639.2003.tb00017.x

1 reference

10.1111/J.1750-3639.2003.TB00017.X

https://api.crossref.org/works/10.1111/J.1750-3639.2003.TB00017.X

1 January 2024

Brain Pathology

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

13

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

2

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

176-184

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine

2

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Contribution of O6‐methylguanine‐DNA methyltransferase to monofunctional alkylating‐agent resistance in human brain tumor—derived cell lines

3

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Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene

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Pattern of mutant p53 expression in human astrocytomas suggests the existence of alternate pathways of tumorigenesis

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Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli

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Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value.

7

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

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Prediction of clinical course of diffusely infiltrating astrocytomas from telomerase expression and quantitated activity level

12

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

13

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1 January 2024

Accumulation of p53 and Ki-67 expression do not predict survival in patients with fibrillary astrocytomas or the response of these tumors to radiotherapy.

14

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1 January 2024

Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.

15

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1 January 2024

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study.

16

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Increased drug resistance following retroviral gene transfer of a chimeric P-enolpyruvate carboxykinase (GTP)-bacterial O6-alkylguanine-DNA alkyltransferase gene into NRK cells

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Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

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Analysis of prognostic and survival factors related to treatment of low-grade astrocytomas in adults

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Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

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p14ARF deletion and methylation in genetic pathways to glioblastomas.

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Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

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Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas

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Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas.

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Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas

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Methylation of the p73 gene in gliomas

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Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

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Identifiers

10.1111/J.1750-3639.2003.TB00017.X

0 references

PMC publication ID

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12744471

1 January 2024

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 February 2018

http://europepmc.org/abstract/MED/12744471

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