(Q48325589)

http://europepmc.org/abstract/MED/28158562

10 February 2018

title

Increased cytoplasmic TDP-43 reduces global protein synthesis by interacting with RACK1 on polyribosomes. (English)

1 reference

http://europepmc.org/abstract/MED/28158562

10 February 2018

author

Melissa E. Murray

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Marcello Ceci

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

2

Raffaella Scardigli

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Arianna Russo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Federico La Regina

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Nicla Romano

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Dennis W Dickson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Benjamin Wolozin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Antonino Cattaneo

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

1 February 2017

1 reference

http://europepmc.org/abstract/MED/28158562

10 February 2018

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

1407-1418

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK-eIF4E Axis.

11 June 2020

cites work

1 reference

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Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP

8 September 2018

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8 September 2018

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Translational control by 5'-untranslated regions of eukaryotic mRNAs

8 September 2018

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Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

8 September 2018

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Working hard at the nexus between cell signaling and the ribosomal machinery: An insight into the roles of RACK1 in translational regulation

8 September 2018

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Old versus New Mechanisms in the Pathogenesis of ALS.

8 September 2018

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Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?

8 September 2018

1 reference

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Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

8 September 2018

1 reference

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Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43.

8 September 2018

1 reference

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Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis

8 September 2018

1 reference

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ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor

8 September 2018

1 reference

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Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Reactivation of stalled polyribosomes in synaptic plasticity

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

RACK1 to the future--a historical perspective

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43)

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

RACK1 is a ribosome scaffold protein for β-actin mRNA/ZBP1 complex

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

TDP-43 is recruited to stress granules in conditions of oxidative insult.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Rethinking ALS: the FUS about TDP-43.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Direct Link between RACK1 Function and Localization at the Ribosome In Vivo

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Structural determinants of the cellular localization and shuttling of TDP-43.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

RACK1 mediates activation of JNK by protein kinase C [corrected].

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

RACK1: a novel substrate for the Src protein-tyrosine kinase

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Receptor-mediated activation of protein kinase C in hippocampal long-term potentiation: facts, problems and implications

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6075552

8 September 2018

Identifiers

DOI

10.1093/HMG/DDX035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28158562%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference