(Q48413482)

11 February 2018

title

Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. (English)

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11 February 2018

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6

George Perry

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11 February 2018

2

Mark A Smith

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11 February 2018

3

Sandra L Siedlak

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11 February 2018

Mark E. Obrenovich

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object named as

Mark E Obrenovich

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11 February 2018

Jack Fernando Bravo-Torres

5

object named as

Jack C de la Torre

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11 February 2018

author name string

Shu G Chen

4

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11 February 2018

Gjumrakch Aliev

7

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11 February 2018

publication date

1 August 2006

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11 February 2018

published in

Neurotoxicity Research

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11 February 2018

volume

10

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11 February 2018

issue

1

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11 February 2018

page(s)

43-56

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11 February 2018

https://scigraph.springernature.com/pub.10.1007/bf03033333

exact match

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cites work

Oxidative damage is the earliest event in Alzheimer disease

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF03033333

Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF03033333

Cerebral blood flow and histopathological changes following permanent bilateral carotid artery ligation in Wistar rats.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF03033333

Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin

21 January 2018

1 reference

12 December 2020

Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes

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12 December 2020

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease

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12 December 2020

Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation

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12 December 2020

Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease

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12 December 2020

Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor

1 reference

12 December 2020

Differential G protein receptor kinase 2 expression in compensated hypertrophy and heart failure after myocardial infarction in the rat

1 reference

12 December 2020

Distribution of G-protein-coupled receptor kinase (GRK) isoforms 2, 3, 5 and 6 mRNA in the rat brain

1 reference

12 December 2020

Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization

1 reference

12 December 2020

Alterations in angiotensin AT1 and AT2 receptor subtype levels in brain regions from patients with neurodegenerative disorders

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12 December 2020

Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats

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12 December 2020

Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease.

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12 December 2020

Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.

1 reference

12 December 2020

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.

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12 December 2020

Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

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12 December 2020

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure

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12 December 2020

GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin.

1 reference

12 December 2020

Selective regulation of G protein-coupled receptor-mediated signaling by G protein-coupled receptor kinase 2 in FRTL-5 cells: analysis of thyrotropin, alpha(1B)-adrenergic, and A(1) adenosine receptor-mediated responses

1 reference

12 December 2020

Correlates between nuclear magnetic resonance spectroscopy, diffusion weighted imaging, and CA1 morphometry following chronic brain ischemia

1 reference

12 December 2020

Aged but not young rats develop metabolic, memory deficits after chronic brain ischaemia

1 reference

12 December 2020

Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease

1 reference

12 December 2020

Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets

1 reference

12 December 2020

Agonist-dependent phosphorylation of the G protein-coupled receptor kinase 2 (GRK2) by Src tyrosine kinase

1 reference

12 December 2020

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

1 reference

12 December 2020

A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

1 reference

12 December 2020

Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord

1 reference

12 December 2020

The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease

1 reference

12 December 2020

Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation.

1 reference

12 December 2020

Modulation of metabotropic glutamate receptors as potential treatment for acute and chronic neurodegenerative disorders

1 reference

12 December 2020

MAPK-dependent Degradation of G Protein-coupled Receptor Kinase 2

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12 December 2020

Alterations of beta-adrenoceptor responsiveness in postischemic myocardium after 72 h of reperfusion

1 reference

12 December 2020

Regulation of G protein-coupled receptor kinases by caveolin

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12 December 2020

Non-visual GRKs: are we seeing the whole picture?

1 reference

12 December 2020

Partial or global rat brain ischemia: the SCOT model

1 reference

12 December 2020

Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction.

1 reference

12 December 2020

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

1 reference

12 December 2020

Mitochondrial failures in Alzheimer's disease

1 reference

12 December 2020

Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity

1 reference

12 December 2020

Return of ATP/PCr and EEG after 75 min of global brain ischemia

1 reference

12 December 2020

Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development: effect of hypothyroidism.

1 reference

12 December 2020

Activation of beta-adrenergic receptor kinase during myocardial ischemia

1 reference

12 December 2020

Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation

1 reference

12 December 2020

The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin

1 reference

12 December 2020

Role of G protein-coupled receptor kinase 2 and arrestins in beta-adrenergic receptor internalization

1 reference

12 December 2020

Expression of GRK2 is increased in the left ventricles of cardiomyopathic hamsters

1 reference

12 December 2020

Deactivation of vasodilator responses by GRK2 overexpression: a mechanism or the mechanism for hypertension?

1 reference

12 December 2020

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

1 reference

12 December 2020

Abortive apoptosis in Alzheimer's disease.

1 reference

12 December 2020

Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.

1 reference

12 December 2020

p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats

1 reference

12 December 2020

Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells

1 reference

12 December 2020

Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease.

1 reference

12 December 2020

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1 reference

12 December 2020

The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1

1 reference

12 December 2020

Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

1 reference

12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03033333

1 reference

11 February 2018

1 reference

11 February 2018