(Q48435698)

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A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice

scientific article published on 8 November 2016

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice (English)

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

amyotrophic lateral sclerosis

1 reference

based on heuristic

inferred from title

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Moussa B. H. Youdim

4

object named as

Moussa B H Youdim

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

Sagit Golko-Perez

1

object named as

Sagit Golko-Perez

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

5

object named as

Orly Weinreb

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

author name string

Tamar Amit

2

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

Orit Bar-Am

3

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

publication date

8 November 2016

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

Neurotoxicity Research

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

31

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

2

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Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

230-244

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2.

1 reference

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21 January 2018

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

1 reference

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21 January 2018

Molecular signatures of amyotrophic lateral sclerosis disease progression in hind and forelimb muscles of an SOD1(G93A) mouse model

1 reference

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21 January 2018

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

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21 January 2018

Motor performance in rats exposed to severe forebrain ischemia: effect of fasting and 1,3-butanediol.

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21 January 2018

The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice

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21 January 2018

The role of PGC-1 coactivators in aging skeletal muscle and heart

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21 January 2018

Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model.

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21 January 2018

Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis.

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21 January 2018

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

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21 January 2018

Intraspinal implantation of hNT neurons into SOD1 mice with apparent motor deficit

1 reference

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21 January 2018

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

1 reference

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21 January 2018

The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies

1 reference

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21 January 2018

Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation

1 reference

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21 January 2018

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

1 reference

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21 January 2018

Inappropriately chelated iron in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.

1 reference

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21 January 2018

Relationships between disease progression and serum levels of lipid, urate, creatinine and ferritin in Japanese patients with amyotrophic lateral sclerosis: a cross-sectional study

1 reference

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21 January 2018

Low intensity areas observed on T2-weighted magnetic resonance imaging of the cerebral cortex in various neurological diseases.

1 reference

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21 January 2018

Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance.

1 reference

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21 January 2018

Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.

1 reference

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21 January 2018

Role of PGC-1α signaling in skeletal muscle health and disease

1 reference

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21 January 2018

Aluminum, calcium, and iron in the spinal cord of patients with sporadic amyotrophic lateral sclerosis using laser microprobe mass spectroscopy: a preliminary study

1 reference

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21 January 2018

Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12640-016-9677-6

21 January 2018

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice

1 reference

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21 January 2018

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

1 reference

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21 January 2018

Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 tesla MRI and pathology.

1 reference

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21 January 2018

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

1 reference

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21 January 2018

Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: report on the 142nd ENMC international workshop.

1 reference

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21 January 2018

Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model

1 reference

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21 January 2018

The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage

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21 January 2018

Moving toward a predictive and personalized clinical approach in amyotrophic lateral sclerosis: novel developments and future directions in diagnosis, genetics, pathogenesis and therapies

1 reference

https://api.crossref.org/works/10.1007%2FS12640-016-9677-6

21 January 2018

Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1007%2FS12640-016-9677-6

21 January 2018

Amyotrophic lateral sclerosis and skeletal muscle: an update.

1 reference

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21 January 2018

Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy.

1 reference

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21 January 2018

Frontotemporal dementia-amyotrophic lateral sclerosis complex is simulated by neurodegeneration with brain iron accumulation.

1 reference

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21 January 2018

Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes

1 reference

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21 January 2018

Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis

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21 January 2018

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

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21 January 2018

Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

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21 January 2018

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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Establishment and Dysfunction of the Blood-Brain Barrier

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Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons

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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

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Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells.

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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

1 reference

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Prevention of motor neuron degeneration by novel iron chelators in SOD1(G93A) transgenic mice of amyotrophic lateral sclerosis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease

1 reference

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inferred from PubMed ID database lookup

Biotransformation of nitric oxide in the cerebrospinal fluid of amyotrophic lateral sclerosis patients

1 reference

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inferred from PubMed ID database lookup

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

1 reference

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Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis.

1 reference

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inferred from PubMed ID database lookup

Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C2C12 murine myoblasts as a model of skeletal muscle development: morpho-functional characterization.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

1 reference

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Synthesis and evaluation of peptidic metal chelators for neuroprotection in neurodegenerative diseases

1 reference

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12 December 2020

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Identifiers

10.1007/S12640-016-9677-6

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 February 2018

http://europepmc.org/abstract/MED/27826939

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