(Q48435795)

11 February 2018

title

Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes. (English)

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11 February 2018

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12

Helga E de Vries

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11 February 2018

author name string

Ruben van Doorn

1

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11 February 2018

Philip G Nijland

2

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11 February 2018

Nick Dekker

3

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11 February 2018

Maarten E Witte

4

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11 February 2018

Melissa A Lopes-Pinheiro

5

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11 February 2018

Bert van het Hof

6

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11 February 2018

Gijs Kooij

7

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11 February 2018

Arie Reijerkerk

8

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11 February 2018

Christine Dijkstra

9

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11 February 2018

Paul van van der Valk

10

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11 February 2018

Jack van Horssen

11

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11 February 2018

publication date

19 July 2012

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11 February 2018

published in

Acta Neuropathologica

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11 February 2018

volume

124

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11 February 2018

issue

3

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11 February 2018

page(s)

397-410

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11 February 2018

https://scigraph.springernature.com/pub.10.1007/s00401-012-1014-4

exact match

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cites work

Structure and function of the blood-brain barrier

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FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells

21 January 2018

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Acid sphingomyelinase activity triggers microparticle release from glial cells

21 January 2018

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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

21 January 2018

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Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies

21 January 2018

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Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

21 January 2018

1 reference

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Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization.

21 January 2018

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Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability.

21 January 2018

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Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells

21 January 2018

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Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells

21 January 2018

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Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier

21 January 2018

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21 January 2018

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Lipid raft components cholesterol and sphingomyelin increase H+/OH- permeability of phosphatidylcholine membranes.

21 January 2018

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Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts

21 January 2018

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Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae

21 January 2018

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Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein

21 January 2018

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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

21 January 2018

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Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury.

21 January 2018

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Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis

21 January 2018

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Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner

21 January 2018

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The relationship between membrane fluidity and permeabilities to water, solutes, ammonia, and protons

21 January 2018

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Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide

21 January 2018

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

21 January 2018

1 reference

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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha

21 January 2018

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Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes

21 January 2018

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CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide

21 January 2018

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Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis

21 January 2018

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Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis.

21 January 2018

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Sphingosine 1-phosphate receptor signaling

21 January 2018

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Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Lipid sorting in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Ceramide triggers budding of exosome vesicles into multivesicular endosomes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Activation of human endothelial cells by tumor necrosis factor-α results in profound changes in the expression of glycosylation-related genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00401-012-1014-4

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1096/FJ.04-3458FJE

Identifiers

DOI

10.1007/S00401-012-1014-4

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11 February 2018

PubMed ID

22810490

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11 February 2018