(Q48464575)

11 February 2018

title

Increased leptin expression in the dorsal vagal complex suppresses adiposity without affecting energy intake and metabolic hormones (English)

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11 February 2018

author name string

Stéphane Boghossian

1

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11 February 2018

Anne Lecklin

2

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11 February 2018

Michael G Dube

3

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11 February 2018

Pushpa S Kalra

4

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11 February 2018

Satya P Kalra

5

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11 February 2018

publication date

1 June 2006

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11 February 2018

published in

Obesity

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11 February 2018

volume

14

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11 February 2018

issue

6

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11 February 2018

page(s)

1003-1009

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11 February 2018

Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes

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The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus.

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Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake

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Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

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Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats

31 March 2020

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Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones

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Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus

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Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy

31 March 2020

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Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin

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Gene-transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy

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Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation

31 March 2020

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Suppression of fat deposition for the life time with gene therapy

31 March 2020

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Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight

31 March 2020

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Adipose tissue as an endocrine organ

31 March 2020

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Brain-adipose tissue cross talk

31 March 2020

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Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake

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Differential regulation of brown adipose and splanchnic sympathetic outflows in rat: roles of raphe and rostral ventrolateral medulla neurons

31 March 2020

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Neuroanatomical specificity of the circuits controlling sympathetic outflow to different targets

31 March 2020

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Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels

31 March 2020

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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

31 March 2020

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https://api.crossref.org/works/10.1038%2FOBY.2006.115

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Disruption in neuropeptide Y and leptin signaling in obese ventromedial hypothalamic-lesioned rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Evidence that dark-phase hyperphagia induced by neurotoxin 6-hydroxydopamine may be due to decreased leptin and increased neuropeptide Y signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

Adipose tissue cellularity and apoptosis after intracerebroventricular injections of leptin and 21 days of recovery in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2006.115

31 March 2020

Identifiers

DOI

10.1038/OBY.2006.115

1 reference

11 February 2018

1 reference

11 February 2018