(Q48469041)

English

Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease.

scientific article published on 31 August 2016

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scholarly article

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer's Disease. (English)

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Alzheimer's disease

0 references

author name string

Susan A Farr

1

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Karin E Sandoval

2

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Michael L Niehoff

3

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Ken A Witt

4

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Vijaya B Kumar

5

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

John E Morley

6

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

publication date

31 August 2016

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

Journal of Alzheimer's Disease

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

54

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

4

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

1339-1348

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

GSK-3: Functional Insights from Cell Biology and Animal Models

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Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

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Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

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Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.

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Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice

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Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

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Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

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Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice.

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21 January 2018

SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways

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Identifiers

10.3233/JAD-160416

0 references

1 reference

Europe PubMed Central

11 February 2018

http://europepmc.org/abstract/MED/27589526

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