(Q48485610)

11 February 2018

title

In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy. (English)

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11 February 2018

main subject

spinal muscular atrophy

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2

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11 February 2018

Kirsten Haastert-Talini

4

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11 February 2018

Florian A. Siebzehnrübl

6

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11 February 2018

Peter Claus

9

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11 February 2018

Markus Riessland

object named as

Markus Riessland

7

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author name string

Eric Hahnen

1

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11 February 2018

Lars Brichta

3

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11 February 2018

Christian Tränkle

5

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11 February 2018

Irmgard Hölker

8

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11 February 2018

Johann Romstöck

10

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11 February 2018

Rolf Buslei

11

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11 February 2018

Brunhilde Wirth

12

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11 February 2018

Ingmar Blümcke

13

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11 February 2018

language of work or name

English

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publication date

1 July 2006

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11 February 2018

Journal of Neurochemistry

published in

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11 February 2018

volume

98

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11 February 2018

issue

1

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11 February 2018

page(s)

193-202

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11 February 2018

Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy

cites work

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Expression of the SMN gene, the spinal muscular atrophy determining gene, in the mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Treatment of spinal muscular atrophy by sodium butyrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Valproate induces replication-independent active DNA demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

The SMN genes are subject to transcriptional regulation during cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Rat embryonic motoneurons in long-term co-culture with Schwann cells--a system to investigate motoneuron diseases on a cellular level in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

A microplate reader-based nonisotopic histone deacetylase activity assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Subtype selective substrates for histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Identification of novel isoform-selective inhibitors within class I histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

The role of histone acetylation in SMN gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Identification and characterization of a spinal muscular atrophy-determining gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Histone Deacetylase Inhibitors

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Animal models of spinal muscular atrophy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

A simple method for organotypic cultures of nervous tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Valproic acid increases SMN levels in spinal muscular atrophy patient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.03868.X

10.1111/J.1471-4159.2006.03868.X

21 January 2018

Identifiers

DOI

1 reference

11 February 2018

PubMed ID

16805808

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11 February 2018