(Q48501239)

12 February 2018

title

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation (English)

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12 February 2018

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7

Eleonora Aronica

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12 February 2018

6

Helga E de Vries

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12 February 2018

author name string

Erwin A van Vliet

1

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12 February 2018

Grazia Forte

2

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12 February 2018

Linda Holtman

3

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12 February 2018

Jeroen C G den Burger

4

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12 February 2018

Arno Sinjewel

5

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12 February 2018

Jan A Gorter

8

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12 February 2018

publication date

21 May 2012

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12 February 2018

published in

Epilepsia

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12 February 2018

volume

53

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12 February 2018

issue

7

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12 February 2018

page(s)

1254-1263

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12 February 2018

Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy

cites work

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy

21 January 2018

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Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats.

21 January 2018

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Rapamycin: brain excitability studied in vitro

21 January 2018

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Emerging concepts in the pathogenesis of epilepsy and epileptogenesis

21 January 2018

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Rapamycin is a neuroprotective treatment for traumatic brain injury.

21 January 2018

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A role for leukocyte-endothelial adhesion mechanisms in epilepsy

21 January 2018

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Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons.

21 January 2018

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Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

21 January 2018

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The NINDS epilepsy research benchmarks

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

The role of brain edema in epileptic brain damage induced by systemic kainic acid injection

21 January 2018

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Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia

21 January 2018

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Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research

21 January 2018

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Seizure-promoting effect of blood-brain barrier disruption

21 January 2018

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Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics

21 January 2018

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The etiological role of blood-brain barrier dysfunction in seizure disorders

21 January 2018

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Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression

21 January 2018

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The blood-brain barrier and epilepsy

21 January 2018

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Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons

21 January 2018

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Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.

21 January 2018

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Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury

21 January 2018

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The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol

21 January 2018

1 reference

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Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

The role of inflammation in epilepsy

21 January 2018

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Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

21 January 2018

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Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1528-1167.2012.03513.X

Blood-brain barrier changes with kainic acid-induced limbic seizures.

21 January 2018

1 reference

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10.1111/J.1528-1167.2012.03513.X

21 January 2018

Identifiers

DOI

1 reference

12 February 2018

1 reference

12 February 2018