(Q48513598)

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Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Alzheimer's disease

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author name string

Barbara Biscaro

1

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Olle Lindvall

2

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Giuseppina Tesco

3

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Christine T Ekdahl

4

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Roger M Nitsch

5

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

publication date

8 May 2012

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

Neurodegenerative Diseases

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

9

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

4

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

187-198

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7068786/fullTextXML

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Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Tumor necrosis factor-alpha and interleukin-18 modulate neuronal cell fate in embryonic neural progenitor culture

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Chemical and immunological heterogeneity of fibrillar amyloid in plaques of Alzheimer's disease and Down's syndrome brains revealed by confocal microscopy

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Functional neurogenesis in the adult hippocampus

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Prospects for minocycline neuroprotection

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part II: Oncology, chemotherapy and carcinogenesis

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Rats with lesions of the hippocampus are impaired on the delayed nonmatching-to-sample task

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Amyloid flirting with synaptic failure: towards a comprehensive view of Alzheimer's disease pathogenesis.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Inflammation regulates functional integration of neurons born in adult brain.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Neurogenesis in the adult brain: new strategies for central nervous system diseases

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

based on heuristic

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Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Adult neurogenesis in the mammalian central nervous system

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Apoptotic cascades as possible targets for inhibiting cell death in Huntington's disease

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Brain inflammation and adult neurogenesis: the dual role of microglia

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Mechanisms and functional implications of adult neurogenesis

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus.

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Spatial relational memory requires hippocampal adult neurogenesis

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

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The efficiency of systematic sampling in stereology and its prediction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

based on heuristic

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Inflammation is detrimental for neurogenesis in adult brain

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https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for adult neurogenesis in spatial long-term memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22584394

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1159/000330363

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/22584394

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