(Q48530570)

12 February 2018

title

Insights into the stereospecificity of ketoreduction in a modular polyketide synthase. (English)

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12 February 2018

author

Frank Schulz

4

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12 February 2018

Peter Leadlay

5

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12 February 2018

Manuela Tosin

object named as

Manuela Tosin

2

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author name string

David H Kwan

1

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12 February 2018

Nadin Schläger

3

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12 February 2018

publication date

21 February 2011

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12 February 2018

Organic and Biomolecular Chemistry

published in

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12 February 2018

volume

9

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12 February 2018

issue

7

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12 February 2018

page(s)

2053-2056

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12 February 2018

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

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Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

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The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

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A tylosin ketoreductase reveals how chirality is determined in polyketides

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Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

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Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro

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Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase

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21 January 2018

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21 January 2018

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A polylinker approach to reductive loop swaps in modular polyketide synthases

21 January 2018

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Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

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Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity

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Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

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Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

21 January 2018

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Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.

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Insights into protein-protein and enzyme-substrate interactions in modular polyketide synthases.

21 January 2018

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Structure-based dissociation of a type I polyketide synthase module

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C1OB00022E

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12 February 2018

PubMed ID

21340070

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12 February 2018