(Q48595147)

13 February 2018

title

Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224. (English)

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13 February 2018

7

Hugo A Katus

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13 February 2018

author name string

Panagiotis Xynogalos

1

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13 February 2018

Claudia Seyler

2

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13 February 2018

Daniel Scherer

3

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13 February 2018

Christoph Koepple

4

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13 February 2018

Eberhard P Scholz

5

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13 February 2018

Dierk Thomas

6

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13 February 2018

Edgar Zitron

8

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13 February 2018

publication date

4 September 2014

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13 February 2018

Naunyn-Schmiedeberg's Archives of Pharmacology

published in

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13 February 2018

volume

387

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13 February 2018

issue

12

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13 February 2018

page(s)

1153-1161

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13 February 2018

Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.

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Clinical update on the management of atrial fibrillation.

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The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

21 January 2018

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The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis

21 January 2018

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Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action poten

21 January 2018

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Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators

21 January 2018

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Carvedilol inhibits Kir2.3 channels by interference with PIP₂-channel interaction

21 January 2018

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Electrophysiologic characterization of dronedarone in guinea pig ventricular cells

21 January 2018

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Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation

21 January 2018

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Cytoplasmic ATP-dependent regulation of ion transporters and channels: mechanisms and messengers

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Effect of dronedarone on cardiovascular events in atrial fibrillation

21 January 2018

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Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding

21 January 2018

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Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

21 January 2018

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Follicular tissues reduce drug effects on ion channels in oocytes of Xenopus laevis

21 January 2018

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Up-regulation of the inward rectifier K+ current (I K1) in the mouse heart accelerates and stabilizes rotors.

21 January 2018

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Specific residues of the cytoplasmic domains of cardiac inward rectifier potassium channels are effective antifibrillatory targets

21 January 2018

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Structural bases for the different anti-fibrillatory effects of chloroquine and quinidine

21 January 2018

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Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions

21 January 2018

1 reference

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Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome

21 January 2018

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The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel

21 January 2018

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Specificity of activation by phosphoinositides determines lipid regulation of Kir channels

21 January 2018

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Short QT syndrome: successful prevention of sudden cardiac death in an adolescent by implantable cardioverter-defibrillator treatment for primary prophylaxis.

21 January 2018

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21 January 2018

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Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents

21 January 2018

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Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter

21 January 2018

1 reference

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Acute effects of dronedarone on both components of the cardiac delayed rectifier K+ current, HERG and KvLQT1/minK potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1045-6

Kir 2.1 channelopathies: the Andersen-Tawil syndrome

21 January 2018

1 reference

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Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome)

21 January 2018

1 reference

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Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1045-6

Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1045-6

Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle

21 January 2018

1 reference

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A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation

21 January 2018

1 reference

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Phosphatidylinositol-4,5-bisphosphate (PIP2) regulation of strong inward rectifier Kir2.1 channels: multilevel positive cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1045-6

Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1045-6

Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-014-1045-6

Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels

21 January 2018

1 reference

12 December 2020

Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle

1 reference

12 December 2020

Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation

1 reference

12 December 2020

Ionic mechanisms of electrical remodeling in human atrial fibrillation

1 reference

12 December 2020

Amiodarone blocks the inward rectifier potassium channel in isolated guinea pig ventricular cells.

1 reference

12 December 2020

The antimalarial drug mefloquine inhibits cardiac inward rectifier K+ channels: evidence for interference in PIP2-channel interaction

1 reference

12 December 2020

Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular myocytes

1 reference

12 December 2020

10.1007/S00210-014-1045-6

Identifiers

DOI

1 reference

13 February 2018

release_yyfzkottiva65dhf4cyvt2cpfe

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yyfzkottiva65dhf4cyvt2cpfe

24 November 2022

mapped directly with Wikidata item

1 reference

13 February 2018