(Q48595827)

13 February 2018

title

Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II. (English)

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13 February 2018

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Gunther Wennemuth

8

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author name string

Malin H Stridh

1

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13 February 2018

Marco D Alt

2

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13 February 2018

Sarah Wittmann

3

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13 February 2018

Hella Heidtmann

4

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13 February 2018

Mayank Aggarwal

5

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13 February 2018

Brigitte Riederer

6

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13 February 2018

Ursula Seidler

7

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13 February 2018

Robert McKenna

9

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13 February 2018

Joachim W Deitmer

10

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13 February 2018

Holger M Becker

11

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13 February 2018

language of work or name

English

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publication date

25 March 2012

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13 February 2018

published in

Journal of Physiology

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13 February 2018

volume

590

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13 February 2018

issue

10

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13 February 2018

page(s)

2333-2351

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13 February 2018

Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II

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Astrocyte-neuron lactate transport is required for long-term memory formation

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Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.

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Food for thought: the importance of glucose and other energy substrates for sustaining brain function under varying levels of activity

8 September 2018

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General requirement for harvesting antennae at ca and h channels and transporters

8 September 2018

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Nonenzymatic augmentation of lactate transport via monocarboxylate transporter isoform 4 by carbonic anhydrase II.

8 September 2018

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Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle

8 September 2018

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8 September 2018

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Nonenzymatic proton handling by carbonic anhydrase II during H+-lactate cotransport via monocarboxylate transporter 1.

8 September 2018

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Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis

8 September 2018

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Supply and demand in cerebral energy metabolism: the role of nutrient transporters

8 September 2018

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Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter

8 September 2018

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Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism

8 September 2018

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Localized proton microcircuits at the biological membrane-water interface

8 September 2018

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Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytes

8 September 2018

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Transport activity of MCT1 expressed in Xenopus oocytes is increased by interaction with carbonic anhydrase

8 September 2018

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A procedure for culturing astrocytes from white matter and the application of the siRNA technique for silencing the expression of their specific marker, S100A4.

8 September 2018

1 reference

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Monocarboxylate transporters in the central nervous system: distribution, regulation and function.

8 September 2018

1 reference

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Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

8 September 2018

1 reference

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Coot: model-building tools for molecular graphics

8 September 2018

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The bicarbonate transport metabolon

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Surface-mediated proton-transfer reactions in membrane-bound proteins

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Astrocytes and synaptosomes transport and metabolize lactate and acetate differently

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Facilitated lactate transport by MCT1 when coexpressed with the sodium bicarbonate cotransporter (NBC) in Xenopus oocytes

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain

8 September 2018

1 reference

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Lactate is a preferential oxidative energy substrate over glucose for neurons in culture

8 September 2018

1 reference

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Food for thought: challenging the dogmas

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

The loop between helix 4 and helix 5 in the monocarboxylate transporter MCT1 is important for substrate selection and protein stability

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Cell-specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures

8 September 2018

1 reference

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Ischemia-induced changes in monocarboxylate transporter 1 reactive cells in rat hippocampus

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Surface carbonic anhydrase activity on astrocytes and neurons facilitates lactate transport.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Strategies for metabolic exchange between glial cells and neurons

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Identification of the carbonic anhydrase II binding site in the Cl(-)/HCO(3)(-) anion exchanger AE1

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte C1-/HCO3- exchanger

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Expression of the monocarboxylate transporter MCT2 by rat brain glia.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Intracellular pH regulation in cultured astrocytes from rat hippocampus. II. Electrogenic Na/HCO3 cotransport

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Incorporation of radioactivity from [14C]lactate into the glycogen of cultured mouse astroglial cells. Evidence for gluconeogenesis in brain cells.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

The kinetics, substrate and inhibitor specificity of the lactate transporter of Ehrlich-Lettre tumour cells studied with the intracellular pH indicator BCECF.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Neurotransmitters regulate energy metabolism in astrocytes: implications for the metabolic trafficking between neural cells.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Developmental modulations of blood-brain barrier permeability as an indicator of changing nutritional requirements in the brain.

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Kinetic analysis of L-lactate transport in human erythrocytes via the monocarboxylate-specific carrier system.

8 September 2018

1 reference

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Glial Cell Markers in the Reeler Mutant Mouse: A Biochemical and Immunohistological Study

8 September 2018

1 reference

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Lactate as energy source for brain in glucose-6-phosphatase deficient child

8 September 2018

1 reference

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Ketone-body utilization by adult and suckling rat brain in vivo

8 September 2018

1 reference

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N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome

8 September 2018

1 reference

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Regional ketone body utilization by rat brain in starvation and diabetes

8 September 2018

1 reference

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Lactate, 3-hydroxybutyrate, and glucose as substrates for the early postnatal rat brain

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Electrogenic sodium-dependent bicarbonate secretion by glial cells of the leech central nervous system

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

Induction processes in blood-brain transfer of ketone bodies during starvation

8 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3424756

The dynamics of proton transfer between adjacent sites

8 September 2018

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Reporting ethical matters in the Journal of Physiology: standards and advice

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Activity-dependent pH shifts in hippocampal slices from normal and carbonic anhydrase II-deficient mice

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Stimulus-evoked changes of extra- and intracellular pH in the leech central nervous system. I. Bicarbonate dependence

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35 Carbonic anhydrase: Oxygen-18 exchange catalyzed by an enzyme with rate-contributing Proton-transfer steps

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Evidence that glial cells modulate extracellular pH transients induced by neuronal activity in the leech central nervous system

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Carbonic Anhydrase Activity Associated with the Cyanobacterium Synechococcus PCC7942

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Lactate production and release in cultured astrocytes

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12 December 2020

The metabolism of [3-(13)C]lactate in the rat brain is specific of a pyruvate carboxylase-deprived compartment

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12 December 2020

Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter

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Membrane potential dependence of intracellular pH regulation by identified glial cells in the leech central nervous system

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10.1113/JPHYSIOL.2011.220152

Identifiers

DOI

1 reference

13 February 2018

0 references

1 reference

13 February 2018