(Q48684446)

14 February 2018

title

The IGF-I receptor in cell growth, transformation and apoptosis. (English)

1 reference

14 February 2018

1 reference

R Baserga

1

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14 February 2018

A Hongo

2

1 reference

14 February 2018

M Rubini

3

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14 February 2018

M Prisco

4

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14 February 2018

B Valentinis

5

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14 February 2018

publication date

1 June 1997

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14 February 2018

Biochimica et Biophysica Acta

published in

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14 February 2018

volume

1332

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14 February 2018

page(s)

F105-26

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14 February 2018

issue

3

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14 February 2018

Mutational analysis of insulin receptor function: consensus and controversy

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Purification and characterization of a unique high molecular weight form of insulin-like growth factor II.

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The E-domain peptide of rat pro-insulin-like growth factor II (proIGF-II): properties of the peptide in serum and production by rat cell lines

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7 January 2021

Binding specificities and transducing function of the different molecular weight forms of insulin-like growth factor-II (IGF-II) on IGF-I receptors.

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7 January 2021

A comparison of the biological activity of the recombinant intact and truncated insulin-like growth factor 1 (IGF-1).

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7 January 2021

The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene

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7 January 2021

Insulin signalling: the role of insulin receptor substrate 1

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7 January 2021

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

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7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

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7 January 2021

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

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7 January 2021

Signal transduction. How receptors turn Ras on.

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7 January 2021

Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent

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7 January 2021

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

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7 January 2021

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

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7 January 2021

Cytokine receptor signalling

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7 January 2021

Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases

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7 January 2021

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

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7 January 2021

Association of insulin receptor substrate-1 with integrins

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7 January 2021

Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules

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7 January 2021

Association of insulin receptor substrate 1 with simian virus 40 large T antigen

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7 January 2021

Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase

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7 January 2021

The pathway to signal achievement

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7 January 2021

Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

1 reference

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7 January 2021

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

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7 January 2021

Transcriptional regulation by extracellular signals: mechanisms and specificity

1 reference

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7 January 2021

A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor

1 reference

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7 January 2021

Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Roles of insulinlike growth factor 1 (IGF-1) and the IGF-1 receptor in epidermal growth factor-stimulated growth of 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

The role of the IGF-1 receptor in the stimulation of cells by short pulses of growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Oncogenes and the strategy of growth factors

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7 January 2021

Alterations in the responsiveness of senescent cells to growth factors

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7 January 2021

Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells

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https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Role of insulin-like growth factors in embryonic and postnatal growth

1 reference

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7 January 2021

The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA.

1 reference

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7 January 2021

Serum Levels of Insulin-Like Growth Factor (IGF) and IGF Binding Protein in Constitutionally Tall Children and Adolescents*

1 reference

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7 January 2021

Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

1 reference

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7 January 2021

Growth enhancement of transgenic mice expressing human insulin-like growth factor I

1 reference

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7 January 2021

Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Characterization of the growth of murine fibroblasts that express human insulin receptors. I. The effect of insulin in the absence of other growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor).

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https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor

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https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Interference of the IGF system as a strategy to inhibit breast cancer growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Mutant IGF-I receptors as dominant negatives for growth and transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Mechanisms and genes of cellular suicide

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7 January 2021

Contenders in FasL/TNF death signaling

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7 January 2021

Apoptosis in cancer therapy: crossing the threshold

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https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Insulin-like growth factor 1 supports embryonic nerve cell survival

1 reference

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7 January 2021

Insulin-like growth factor receptors. Implications for nervous system function

1 reference

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7 January 2021

Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Activation of the insulin-like growth factor-I receptor inhibits tumor necrosis factor-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

ICE family proteases: mediators of all apoptotic cell death?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Survival and development of larval Onchocerca volvulus in diffusion chambers implanted in primate and rodent hosts.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

The relative effects of different types of growth factors on DNA replication, mitosis, and cellular enlargement

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Activation of the ribosomal DNA promoter in cells exposed to insulinlike growth factor I.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

IGF-I increases C-fos expression in FRTL5 rat thyroid cells by activating the C-fos promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Multiple Hormones Stimulate the Production of Somatomedin by Cultured Human Fibroblasts*

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Platelet-derived growth factor increases the activity of the promoter of the insulin-like growth factor-1 (IGF-1) receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Fibroblast Growth Factor Inhibits Insulin-Like Growth Factor-II (IGF-II) Gene Expression and Increases IGF-I Receptor Abundance in BC3H-1 Muscle Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

TPA-induced neurite formation in a neuroblastoma cell line (SH-SY5Y) is associated with increased IGF-I receptor mRNA and binding

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Insulin-like growth factors in central nervous system tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Effects of an Igf1 gene null mutation on mouse reproduction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Intracellular transactivation of the insulin-like growth factor I receptor by an epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

The role of the IGF-I receptor in apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Constitutively expressed c-myb abrogates the requirement for insulinlike growth factor 1 in 3T3 fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

The IGF-I receptor gene promoter is a molecular target for the Ewing's sarcoma-Wilms' tumor 1 fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Inhibition of cellular proliferation by the Wilms' tumor suppressor WT1 is associated with suppression of insulin-like growth factor I receptor gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Insulin-like growth factors and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Characterization of insulin, insulin-like growth factors I and II, and growth hormone receptors on human leukemic lymphoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Regulation of insulin receptor functions by a peptide derived from a major histocompatibility complex class I antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

TGFbeta signaling: receptors, transducers, and Mad proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Antiapoptosis potential of bcl-2 oncogene by dephosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

Insulin activates nuclear factor kappa B in mammalian cells through a Raf-1-mediated pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900007-3

7 January 2021

10.1016/S0304-419X(97)00007-3

Identifiers

DOI

1 reference

14 February 2018

PubMed ID

9196021

1 reference

14 February 2018