(Q48706148)

14 February 2018

title

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model. (English)

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14 February 2018

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Y Igari

1

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14 February 2018

Y Sugiyama

2

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14 February 2018

Y Sawada

3

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14 February 2018

T Iga

4

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14 February 2018

M Hanano

5

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14 February 2018

publication date

1 December 1983

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14 February 2018

Journal of Pharmacokinetics and Pharmacodynamics

published in

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14 February 2018

volume

11

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14 February 2018

page(s)

577-593

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14 February 2018

issue

6

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14 February 2018

https://scigraph.springernature.com/pub.10.1007/bf01059058

exact match

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cites work

A review of the applications of physiologically based pharmacokinetic modeling

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https://api.crossref.org/works/10.1007%2FBF01059058

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Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine (ARA-C) deamination in several species.

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In vitro and in vivo assessment of hepatic and extrahepatic metabolism of diazepam in the rat.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF01059058

Clearance of diazepam can be impaired by its major metabolite desmethyldiazepam.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF01059058

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

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Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data

21 January 2018

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Physiologically based pharmacokinetic models for anticancer drugs

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12 December 2020

Biliary excretion of diazepam in the rat.

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Lidocaine disposition kinetics in monkey and man. I. Prediction by a perfusion model.

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A Simple Method for Determining Diazepam and Its Major Metabolites in Biological Fluids: Application in Bioavailability Studies

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An electric analogue for uptake and exchange of inert gases and other agents.

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Relation between binding to plasma protein, apparent volume of distribution, and rate constants of disposition and elimination for chlorpromazine in three species.

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Methotrexate Pharmacokinetics

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Prediction of pulmonary benzo(a)pyrene 4,5-oxide clearance: a pharmacokinetic analysis of epoxide-metabolizing enzymes in rabbit lung

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Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat

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Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat

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In vitro-in vivo correlation of drug metabolism-deamination of 1-β-d-arabinofuranosylcytosine

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Transport and Binding of Methotrexate In Vivo

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The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat

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Kinetic studies on the deethylation of ethoxybenzamide. A comparative study with isolated hepatocytes and liver microsomes of rat

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Estimation of tissue-to-plasma partition coefficients used in physiological pharmacokinetic models

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The effects of age and liver disease on the disposition and elimination of diazepam in adult man

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Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

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12 December 2020

Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species

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12 December 2020

Computer simulation of sulfobromophthalein kinetics in the rat using flow-limited models with extrapolation to man

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12 December 2020

Measurement of the distribution of cardiac output in unanesthetized rats

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12 December 2020

Effects of desmethyldiazepam on diazepam kinetics: a study of effects of a metabolite on parent drug disposition.

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12 December 2020

Physiologically based pharmacokinetic model for digoxin disposition in dogs and its preliminary application to humans

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12 December 2020

A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat

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12 December 2020

In vivo assessment of extrahepatic conjugative metabolism in first pass effects using the model compound phenol

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12 December 2020

Tissue distribution of 14C-diazepam and its metabolites in rats.

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12 December 2020

Identifiers

DOI

10.1007/BF01059058

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14 February 2018

PubMed ID

6678311

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14 February 2018