(Q48785714)

English

The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens.

scientific article published on 9 May 2014

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scholarly article

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens. (English)

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

0 references

nucleus accumbens

1 reference

based on heuristic

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author name string

Mei Huang

1

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Anna R Felix

2

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Dorothy G Flood

3

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Chaya Bhuvaneswaran

4

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Dana Hilt

5

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Gerhard Koenig

6

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Herbert Y Meltzer

7

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

publication date

9 May 2014

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Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

Psychopharmacology

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Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

231

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Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

23

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

4541-4551

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

https://scigraph.springernature.com/pub.10.1007/s00213-014-3596-0

0 references

Sensitization of cortical acetylcholine release by repeated administration of nicotine in rats

1 reference

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M100907, a selective 5-HT2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro.

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SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile

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The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents.

1 reference

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Localized infusions of the partial alpha 7 nicotinic receptor agonist SSR180711 evoke rapid and transient increases in prefrontal glutamate release

1 reference

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The effects of haloperidol and clozapine on extracellular GABA levels in the prefrontal cortex of the rat: an in vivo microdialysis study.

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Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

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alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats

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5-HT3 receptors

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Long-term neurocognitive effects of antipsychotics in schizophrenia: a network meta-analysis.

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Selective stimulation of serotonin2c receptors blocks the enhancement of striatal and accumbal dopamine release induced by nicotine administration

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GABA(A) receptor antagonists enhance cortical acetylcholine release induced by 5-HT(3) receptor blockade in freely moving rats

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Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission.

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Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.

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Glutamatergic neurotransmission modulators as emerging new drugs for schizophrenia

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21 January 2018

The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release

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21 January 2018

Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism

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Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum

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Nicotine increases microdialysate brain amino acid concentrations and induces conditioned place preference.

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The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study.

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A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits

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Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

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A randomized exploratory trial of an α-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia

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Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats

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Glutamate-dopamine crosstalk in the rat prefrontal cortex is modulated by Alpha7 nicotinic receptors and potentiated by PNU-120596.

1 reference

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Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel

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Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

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5-Hydroxytryptamine3 receptors sited on cholinergic axon terminals of human cerebral cortex mediate inhibition of acetylcholine release

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In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems

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DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats

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Brain-selective stimulation of nicotinic receptors by TC-1734 enhances ACh transmission from frontoparietal cortex and memory in rodents

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Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine-induced activation of orexin neurons

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SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia.

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Normalizing effects of EVP-6124, an α-7 nicotinic partial agonist, on event-related potentials and cognition: a proof of concept, randomized trial in patients with schizophrenia

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EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

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Pharmacological characterization of nicotine-induced acetylcholine release in the rat hippocampus in vivo: evidence for a permissive dopamine synapse.

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The effects of cholinergic and dopaminergic antagonists on nicotine-induced cerebral neurotransmitter changes

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Nicotine-induced changes in neurotransmitter levels in brain areas associated with cognitive function

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The 5-HT3 receptor as a therapeutic target

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Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology

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Effect of nicotine on the level of extracellular amino acids in the hippocampus of rat.

1 reference

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21 January 2018

RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents.

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Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN1

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain region effects of clozapine on amino acid and monoamine transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology and pathophysiology of the 5-HT3 receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ventral tegmental area 5-HT receptors: mesolimbic dopamine release and behavioural studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and schizophrenia: beyond the dopamine hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24810107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-014-3596-0

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

1 reference

Europe PubMed Central

15 February 2018

http://europepmc.org/abstract/MED/24810107

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