(Q48912854)

16 February 2018

title

Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, in mdr1a-deficient and mdr1a-competent mice. (English)

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16 February 2018

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Fergus Manford

1

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16 February 2018

Yanira Riffo-Vasquez

2

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16 February 2018

Domenico Spina

3

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16 February 2018

Clive P Page

4

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16 February 2018

Andrew J Hutt

5

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16 February 2018

Vanessa Moore

6

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16 February 2018

Fredrik Johansson

7

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16 February 2018

Ben Forbes

8

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16 February 2018

publication date

1 October 2008

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16 February 2018

Journal of Pharmacy and Pharmacology

published in

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16 February 2018

volume

60

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16 February 2018

issue

10

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16 February 2018

page(s)

1305-1310

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16 February 2018

Pulmonary delivery of peptide drugs: effect of particle size on bioavailability of leuprolide acetate in healthy male volunteers

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Recombinant interleukin-2 treatment decreases P-glycoprotein activity and paclitaxel metabolism in mice.

21 January 2018

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Constitutive expression of p-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures

21 January 2018

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The pharmacokinetics of pulmonary-delivered insulin: a comparison of intratracheal and aerosol administration to the rabbit

21 January 2018

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Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

21 January 2018

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16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Passage of aerosolized BSA and the nona-peptide dDAVP via the respiratory tract in young and adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Transport characteristics of peptides and peptidomimetics: II. Hydroxyethylamine bioisostere-containing peptidomimetics as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

P-glycoprotein efflux pump expression and activity in Calu-3 cells

21 January 2018

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Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Contribution of efflux pump activity to the delivery of pulmonary therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

MDR1-Pgp 170 expression in human bronchus

21 January 2018

1 reference

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Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice

21 January 2018

1 reference

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Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Progress in understanding the structure-activity relationships of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure-absorption relationships and physicochemical profiling of inhaled drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

The complexity of intestinal absorption and exsorption of digoxin in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2FJPP.60.10.0006

21 January 2018

Identifiers

DOI

10.1211/JPP.60.10.0006

1 reference

16 February 2018

1 reference

16 February 2018